PMID: 6105243Jul 12, 1980Paper

Treatment of pruritus of cholestasis by plasma perfusion through USP-charcoal-coated glass beads

Lancet
B H LauterburgG L Carlson

Abstract

The accumulation of bile acids has been implicated in the pathogenesis of pruritus of cholestasis. To study the effect of bile-acid depletion on pruritus, 8 patients with chronic cholestasis and intractable pruritus which had not responded to cholestyramine and/or phenobarbitone underwent plasma perfusion through USP-charcoal-coated glass beads. DSuring twenty-two perfusions, between 957 and 6100 ml of plasma were perfused through charcoal columns, resulting in the removal of 126-795 mumol of bile acids. The mean extraction of the perfused bile acids was 81%. After the perfusions, all patients had prompt relief of their pruritus, lasting from 24 h to 5 months. Although the clinical effect may be due to the removal of unidentified pruritogens other than bile acids, charcoal plasma perfusion may improve the quality of life of incapacitated patients with servere intractable pruritus of cholestasis.

Citations

Feb 1, 1991·Digestive Diseases and Sciences·A PodestaJ P Companc
Jan 1, 1989·Baillière's Clinical Gastroenterology·D R Triger
Jan 9, 2003·The American Journal of Medicine·Ernest N Charlesworth, Vincent S Beltrani
Sep 13, 1980·Lancet
Sep 25, 1998·Journal of Dermatological Science·Y YamaguchiK Yoshikawa
Apr 9, 1992·The New England Journal of Medicine·M W Greaves
Mar 1, 1993·Journal of Gastroenterology and Hepatology·D A Gillespie, C R Vickers
Aug 1, 1981·Artificial Organs·A A Pineda, H F Taswell
Mar 1, 1985·Gut·L B CohenF Schaffner
Apr 1, 1990·Gastroenterology·H A CynamonR P Iafrate
Mar 1, 1986·Journal of the American Academy of Dermatology·S T Denman
Feb 5, 2008·Clinics in Liver Disease·Nora V Bergasa
Jul 1, 1990·The American Journal of Medicine·K D LindorN F LaRusso
Oct 29, 2005·Journal of Hepatology·Nora V Bergasa
Nov 25, 2004·Clinics in Liver Disease·N V Bergasa, E A Jones
Aug 13, 2002·Dermatologic Clinics·Lawrence Etter, Sarah A Myers
May 1, 1981·The American Journal of Medicine·M R FreedmanD R Ferguson
Dec 1, 1993·The Journal of Dermatology·M W Greaves
Apr 6, 2004·Clinics in Liver Disease·Nora V Bergasa
May 1, 1988·Clinical and Experimental Dermatology·I Sarkany
Apr 1, 1986·Journal of Clinical and Hospital Pharmacy·D AdamsE Elias
Dec 1, 1995·Journal of Pediatric Surgery·J C Emond, P F Whitington
Jul 1, 1985·Pediatric Annals·D A Novak, W F Balistreri
Nov 24, 1998·The Annals of Pharmacotherapy·S G Terra, S M Tsunoda
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cataldo DoriaVictor L Scott
Sep 1, 1982·Clinical and Experimental Dermatology·R Camp
Oct 1, 1981·The British Journal of Dermatology·S HishonJ O Hunter
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E A Jones, N V Bergasa
Mar 4, 2000·Journal of Pediatric Gastroenterology and Nutrition·V L NgW F Balistreri
Jan 1, 1992·Scandinavian Journal of Gastroenterology·A A AlarabiB G Danielson
Mar 27, 2003·Alimentary Pharmacology & Therapeutics·M MelaA K Burroughs
May 28, 2004·The International Journal of Artificial Organs·R E StauberM Trauner
Nov 30, 2000·Current Treatment Options in Gastroenterology·J Franco
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D R Beswick, J L Boyer
Jan 1, 1994·Digestive Diseases and Sciences·M Khandelwal, P F Malet

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