Treatment of PSA only recurrence of prostate cancer after prior local therapy

Current Pharmaceutical Design
Judd W Moul

Abstract

Prostate cancer recurrence (after prior local treatment) that is detectable only by a rise in serum prostate specific antigen (PSA) level is a very common problem facing clinicians. Given that the majority of contemporary era men with PSA-only or biochemical recurrence are relatively young and otherwise healthy, treatment requires approaches that both improve clinical outcomes and preserve quality of life. Treatment is in one of two broad categories, additional local therapies, termed "salvage" local therapy and systemic therapies. For radical prostatectomy patients, salvage external beam radiotherapy to the prostate bed is commonly employed, being reserved for early biochemical recurrence in men with low risk at distant metastases. For primary radiation patients, salvage radical prostatectomy or cryotherapy can similarly be used for those men felt not to harbor distant metastases. Systemic therapy generally involves hormonal therapy. Traditional hormonal therapy (orchiectomy, luteinizing hormone-releasing hormone agonists or maximum androgen blockade) is the current mainstay of systemic treatment for biochemical recurrence, although non-traditional approaches, such as antiandrogen monotherapy, are increasingly being used. Ther...Continue Reading

Citations

Feb 25, 2009·Prostate Cancer and Prostatic Diseases·H Van PoppelR Oyen
Mar 17, 2012·European Urology·Vladimir MouravievJ Stephen Jones
Nov 12, 2014·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Megan Johnson ShenMichael A Diefenbach
May 13, 2020·Nature Ecology & Evolution·Ziv FrankensteinAlexander R A Anderson
Apr 12, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K Fizazi

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