PMID: 2508049Jan 1, 1989Paper

Treatment of Pseudomonas lung infection in cystic fibrosis with piperacillin plus tobramycin versus ceftazidime monotherapy: preliminary communication

Pediatric Pulmonology
K De BoeckE Eggermont

Abstract

Twenty-one patients with cystic fibrosis and chronic Pseudomonas lung infection were treated at random with ceftazidime, 150 mg/kg/day, or with piperacillin, 300 mg/kg/day, and tobramycin, 10 and more mg/kg/day for 14 days. On admission and at discharge, body weight, erythrocyte sedimentation rate, white blood cell count, and differential were determined. Pulmonary function analysis and chest X-rays were also obtained on both occasions as was sputum bacteriology. After hospitalization, the patients were followed in the outpatient department for 14-26 months. Both treatments were associated with significant improvement in most of the parameters that were studied, but neither treatment was superior.

Citations

Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Robert E. W. Hancock, David P. Speert
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Matthew N HurleyPatrick Flume
Dec 3, 2016·The Cochrane Database of Systematic Reviews·Heather E Elphick, Alison Scott
Nov 17, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Charlie McLeodThomas L Snelling
Jun 24, 2021·The Cochrane Database of Systematic Reviews·Poppy Holland, Nikki Jahnke

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