PMID: 2124243Dec 1, 1990Paper

Treatment of psoriasis and psoriatic arthritis with interferon gamma

The Journal of Investigative Dermatology
G Fierlbeck, G Rassner

Abstract

In a placebo-controlled double-blind randomized study, 24 patients with psoriatic arthritis were given 28 d of treatment, and in an open study, 56 patients were treated for 9 months. We treated patients with 100 micrograms IFN gamma per subcutaneous injections, which were given daily for the first 2 weeks and then 3 times per week. The principal criterion for evaluation of therapeutic success on arthritis was improvement of the Ritchie joint pain index by at least 25% in the double-blind and 30% in the long-term study. In the double-blind study, the interferon arm was superior to the placebo arm with a statistically significant, one-side error probability of less than 5% in the chi-square test. In the long-term study, IFN gamma caused an improvement in a portion of patients in the first 3 months of therapy. No further improvement was observed after the third month, and patients classified as responders in the first months showed a deterioration of the disease by continuing treatment. The humoral inflammatory parameters did not normalize during therapy. Regression of the skin manifestations could not be observed. IFN gamma is evidently capable of inducing a psoriasis on the injection site. Investigations of IFN gamma serum level...Continue Reading

Citations

Jan 24, 2006·American Journal of Therapeutics·Augustine M ManadanJoel A Block
Oct 15, 2013·The British Journal of Dermatology·E ChristophersM Röcken
Aug 25, 2020·Archives of Toxicology·Jasna Grželj, Marija Sollner Dolenc
Jul 25, 2000·The Cochrane Database of Systematic Reviews·G JonesP Brooks
Jan 5, 2002·American Journal of Clinical Dermatology·C G Jackson
Oct 17, 2019·Frontiers in Immunology·Ruiling LiuQingguo Ruan
Feb 6, 2020·Recent Patents on Nanotechnology·Kalpana Pandey, Nimisha
May 1, 1994·Baillière's Clinical Rheumatology·M L CuéllarL R Espinoza
Jun 1, 1991·Journal of the American Academy of Dermatology·T A Luger, T Schwarz

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