PMID: 2492947Feb 1, 1989Paper

Treatment of pure red-cell aplasia and aplastic anaemia with ciclosporin: long-term clinical effects

European Journal of Haematology
T H TöttermanA Killander

Abstract

6 patients with pure red-cell aplasia were treated with Ciclosporin (Cyclosporine A; CS) alone or combined with prednisolone for a period of 9-46 (median 27) months. Prior to study, 5 cases had refractory disease, steroids were contraindicated in 1, and 4/6 patients, including 2 cases with congenital disease, had a disease duration exceeding 11 years. A complete haematological response was obtained in 5/6 subjects, and a partial response in 1. When the pre-treatment Hb levels (mean +/- S.D. = 64 +/- 13 g/l, range 41-80) for all 6 PRCA patients were compared with the Hb levels after 6 months of CS therapy (104 +/- 17 g/l, 80-125), a significant improvement was registered (p less than 0.005). In half of the patients, remission is maintained with CS as single drug in a dose-dependent manner. We also treated 5 patients with refractory severe aplastic anaemia with CS (1 case) or CS plus prednisolone (4 cases) for 3-27 (median 10) months. Only 1 patient responded. In this case, a complete haematological remission was induced with CS alone, and remission has been maintained for 27 months. Side effects of CS therapy were common but were dose-dependent and reversible, with the exception of persistent nephrotoxicity in 1 patient with pur...Continue Reading

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Citations

Oct 24, 1997·European Journal of Haematology·S MamiyaA B Miura
May 23, 2003·The Korean Journal of Internal Medicine·Chi Young ParkChun Choo Kim
Sep 9, 2011·Journal of Feline Medicine and Surgery·Katrina R Viviano, Julie L Webb
Apr 25, 2000·Journal of Pediatric Hematology/oncology·A J AlessandriJ H Davis
Nov 8, 2005·Annals of Saudi Medicine·Jameel Al-GhazalyAdela Al-Hashdi
May 31, 2008·British Journal of Haematology·Kenichi SawadaMakoto Hirokawa
Nov 1, 1993·Annals of Hematology·T IshiyamaN Tsuruoka
Oct 1, 1994·American Journal of Hematology·Y L Kwong, R H Liang
Mar 1, 1991·American Journal of Hematology·J M CanvinJ B Johnston
Mar 4, 2021·Blood·Carmelo Gurnari, Jaroslaw P Maciejewski

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