PMID: 2113258Apr 1, 1990Paper

Treatment of radiation- and chemotherapy-induced stomatitis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S B CarnelM Barnes

Abstract

Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy. Most therapeutic regimens are empirical, with no scientific basis. The purpose of this study is to determine the efficacy of various topical solutions in the treatment of radiation- or chemotherapy-induced stomatitis. Eighteen patients were entered into a prospective double-blinded study to test several topical solutions: (1) viscous lidocaine with 1% cocaine; (2) dyclonine hydrochloride 1.0% (Dyclone); (3) kaolin-pectin solution, diphenhydramine plus saline (KBS); and (4) a placebo solution. Degree of pain relief, duration of relief, side effects, and palatability were evaluated. The results showed that Dyclone provided the most pain relief. Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, which averaged 50 minutes This study provides objective data and defines useful guidelines for treatment of stomatitis.

References

Feb 1, 1977·Annals of Internal Medicine·G D Weinstein

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Citations

Jul 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L J DiNardo, R A Hendrix
Mar 9, 2012·Expert Opinion on Drug Safety·Suzanne BerkmanTina Alster
Jul 9, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Deborah P SaundersUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jun 15, 2016·Journal of Medical Microbiology·Eline VanlanckerTom Van de Wiele
Feb 13, 2020·JCO Oncology Practice·Timothy J Brown, Arjun Gupta
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Jan E ClarksonStefan Meyer
Aug 24, 2005·International Journal of Palliative Nursing·Clare Marlow, Jeremy Johnson
Apr 27, 2004·Cancer·Edward B RubensteinUNKNOWN International Society for Oral Oncology
Apr 26, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Loren Madden KirkPaul O Lewis
Apr 3, 2019·International Journal of Molecular Sciences·Agnieszka StempniewiczZygmunt Warzecha
May 25, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jun 8, 2017·Frontiers in Oncology·Osama Muhammad MariaThierry Muanza
Mar 31, 2009·Journal of Palliative Medicine·Juliet Jacobsen
Oct 1, 1995·Cancer Control : Journal of the Moffitt Cancer Center·R Quilitz

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