PMID: 8467440Mar 1, 1993Paper

Treatment of rapid cycling bipolar disorder with combination therapy of valproate and lithium

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
V SharmaK Karunaratne

Abstract

Over the past two decades there has been a great deal of interest in the use of anticonvulsants to treat a variety of primary psychiatric disorders. Valproate, one such anticonvulsant, has been found to be effective in the treatment of acute mania, mixed states and rapid cycling disorders. This paper presents the results of an open study with combination therapy of valproate and lithium in a series of nine patients (mean age = 50 years). These patients had previously been treated with various psychotropic agents, including a combination of carbamazepine and lithium. All but one patient showed marked or moderate improvement in their condition. Of particular interest was the observation that in three patients there was evidence of augmentation between valproate and lithium during the depressed phase of their illness. There was significant improvement in their depression within 24 to 48 hours of the addition of lithium to valproate. The combination therapy was very well-tolerated. It is concluded that valproate and lithium combination therapy provides a safe and effective alternative for the treatment of rapid cycling variant of bipolar illness.

References

Jan 11, 1991·Archives of General Psychiatry·H G PopeJ I Hudson
Apr 1, 1990·The American Journal of Psychiatry·J R Calabrese, G A Delucchi
May 1, 1985·Journal of Affective Disorders·H M EmrichD von Zerssen
Feb 1, 1974·Archives of General Psychiatry·D L Dunner, R R Fieve

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Citations

Sep 4, 2004·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Jan 7, 2006·CNS Drugs·Daniel LinLakshmi N Yatham
Feb 24, 1998·Journal of Clinical Psychopharmacology·D A SolomonI W Miller
Jan 26, 2000·Journal of Clinical Psychopharmacology·L L DavisF Petty
Sep 14, 2004·CNS Spectrums·Claudia F BaldassanoJohn P O'Reardon
Feb 13, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Jun 5, 2003·Bipolar Disorders·Charles L Bowden
Jun 26, 2017·Current Psychiatry Reports·Peijun ChenMartha Sajatovic
Jan 8, 2019·Drugs & Aging·Jocelyn Fotso SohSoham Rej
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments
Jun 17, 2003·Acta Psychiatrica Scandinavica·L TondoR J Baldessarini
Mar 18, 2003·Journal of Clinical Psychopharmacology·Carrie L Ernst, Joseph F Goldberg
Jul 3, 2021·Medicina·Ivan ArnoldArmand Hausmann
Nov 7, 1999·The Psychiatric Clinics of North America·N Kilzieh, H S Akiskal

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