PMID: 9185663Jun 1, 1997Paper

Treatment of rat hemiparkinson model with xenogeneic neural transplantation: tolerance induction by anti-T-cell antibodies

Journal of Neuroscience Research
Y OkuraY Matsumoto

Abstract

To obtain basic knowledge for the application of xenogeneic neural transplantation to patients with Parkinson's disease, the rejection process of xenogeneic neural grafts in rats was examined and a therapy to control it was developed. Tissues including the ventral mesencephalon were taken from mouse embryos and transplanted into the right lateral ventricle of mature male rats. Transplanted xenografts were usually rejected by day 15. To prevent the graft rejection, host rats were treated with anti-T-cell receptor alphabeta (anti-TCR alphabeta) or anti-CD2 monoclonal antibody (mAb) or by a combination of the two. Anti-TCR alphabeta (1 mg/kg) and anti-CD2 (7 mg/kg) mAb were administered for 3 consecutive days (day -2, -1, and 0 of transplantation). Although the administration of mAb against either CD2 or TCR alphabeta did not induce tolerance, the combination therapy with anti-CD2 and anti-TCR alphabeta mAb produced graft survival for more than 100 days. The tolerance induced by this combined antibody therapy is antigen specific because rats with long-term surviving neural xenograft accepted a second neural graft from the same donor strain C3H/He mouse, but not from a third-party strain BALB/c mouse, without additional treatment. ...Continue Reading

References

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Citations

Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Roger A Barker, Håkan Widner
Mar 10, 2005·Experimental Neurology·Benoît MelchiorPhilippe Brachet
Jan 11, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Aron BadinE Cozzi
Aug 12, 2005·Neurorehabilitation and Neural Repair·W-L Kuan, R A Barker
Oct 29, 2003·Cell Transplantation·Suchitra Sumitran-HolgerssonJan Holgersson
Dec 17, 2005·Cell Transplantation·Caroline MartinPhilippe Brachet
Oct 6, 2005·Transgenic Research·Caroline MartinBernard Vanhove

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