Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-p-dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reaction of sperm

Toxicology and Applied Pharmacology
F El-SabeawyE Enan

Abstract

Different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (0.1, 1, 5, and 10 micrograms/kg body wt) were administered i.p. to 21-day-old male Sprague-Dawley rats. Control animals received the same volume of the vehicle (acetone:corn oil, 1:19). Body weight and daily food intake were recorded during the 90-day time course of the study. Random samples of five rats were sacrificed at 34, 49, 62, and 90 days of age. Epidermal growth factor receptor (EGFR) in whole testis was measured, as were the activities of c-Src kinase, protein tyrosine kinase (PTK), mitogen-activated protein 2 kinase (MAP2K also termed as Erk2), protein kinase A (PKA), and protein kinase C (PKC). Testicular tissue from 90-day-old rats was evaluated for histopathology, and sperm numbers in whole testis were counted to estimate daily sperm production. The motility of sperm in the vas deferens and caudal segments of the epididymis of 90-day-old rats was measured by computer assisted sperm analysis (CASA) and the function of the sperm was tested by assessment of acrosome reactions. A dose of 10 micrograms/kg resulted in testicular atrophy and histopathologic examination revealed a decrease in the diameter of the seminiferous tubules. Sertoli cell nuclei were c...Continue Reading

References

May 1, 1978·Toxicology and Applied Pharmacology·E E McConnellM W Harris
Jul 30, 1992·Nature·J M KyriakisJ Avruch
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Oct 1, 1992·The Biochemical Journal·D W Meek, A J Street
Jan 1, 1991·Annual Review of Biochemistry·H R Herschman
Jul 1, 1991·Developmental Biology·C GuptaD Ellis
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·J P Whitlock
Jan 15, 1990·Biochemical and Biophysical Research Communications·M MisrahiE Milgrom
Jan 1, 1989·Journal of Biochemical Toxicology·R W MooreR E Peterson
Jun 15, 1985·Toxicology and Applied Pharmacology·R W MooreR E Peterson
Aug 1, 1974·Toxicology and Applied Pharmacology·J G VosJ G Zinkl
Sep 1, 1984·Archives of Environmental Contamination and Toxicology·F MatsumuraD W Bombick
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·M C MaaS J Parsons
May 1, 1995·Environmental Health Perspectives·L J GuilletteH F Percival
Sep 14, 1995·Nature·X J SunM F White
Feb 1, 1993·Current Opinion in Genetics & Development·S J Taylor, D Shalloway
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B R SevetsonJ C Lawrence
Nov 19, 1994·BMJ : British Medical Journal·N E Skakkebaek, N Keiding
Apr 1, 1995·Fertility and Sterility·G W OlsenL I Lipshultz
Jun 1, 1994·Journal of Biochemical Toxicology·E Enan, F Matsumura

❮ Previous
Next ❯

Citations

Jun 1, 2005·Development, Growth & Differentiation·Myung Chan GyeYoung Soo Kim
Nov 20, 2001·Environmental Health Perspectives·L S BaskinT Colborn
Feb 18, 2011·Trends in Pharmacological Sciences·Elissa W P Wong, C Yan Cheng
Jul 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ju-Han LeeNam Hee Won
May 5, 2016·Seminars in Cell & Developmental Biology·Filipe Tenorio Lira NetoMarc Goldstein
Jun 3, 2011·Toxicology and Industrial Health·Hai-Ping YinYing Wang
May 16, 2017·Drug and Chemical Toxicology·Takuya MatsuyamaKazuhiko Mori
Oct 2, 2002·Journal of Applied Toxicology : JAT·C Latchoumycandane, P P Mathur
Jul 13, 2006·Journal of Occupational and Environmental Medicine·Amit GuptaClaus G Roehrborn
Mar 22, 2019·Journal of Nanobiotechnology·Fenju QinJian Tong
May 3, 2011·Polish Journal of Veterinary Sciences·A Dziekońska, J Strzezek
Sep 21, 2013·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Ajinkya A Patil, Ameet V Revankar
Oct 2, 2013·Human Reproduction Update·Alexandra AmaralRafael Oliva
Mar 8, 2014·British Journal of Pharmacology·B BuzadzicV Otasevic
Apr 12, 2020·Archives of Toxicology·Stephenie D ProkopecRaimo Pohjanvirta
Aug 8, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·F El-SabeawyB Lasley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.