Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity

Carcinogenesis
Y LiB T Spear

Abstract

Nuclear factor kappaB (NF-kappaB) is an important stress-induced transcription factor in many cell types, including hepatocytes. Previous studies have shown that reactive oxygen species, including hydrogen peroxide, are potent activators of NF-kappaB. Peroxisome proliferators are a group of rodent chemical carcinogens that have been proposed to act by increasing reactive oxygen in the liver. These results led us to consider whether peroxisome proliferators would increase NF-kappaB activity in the liver. Here we demonstrate that rats fed diets containing the peroxisome proliferator ciprofibrate exhibit increased hepatic NF-kappaB DNA-binding activity. This observation suggests that NF-kappaB may contribute, in part, to peroxisome proliferator-mediated changes in the liver.

Citations

Aug 25, 2001·Journal of Physiology and Biochemistry·S BonillaP Higueret
Mar 7, 2001·Antioxidants & Redox Signaling·I RusynR G Thurman
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J C TharappelH P Glauert
Feb 7, 2009·PPAR Research·Howard P GlauertBrett T Spear
Jan 20, 2004·Critical Reviews in Toxicology·James E KlaunigPenelope A Fenner-Crisp
Mar 5, 1999·Drug Metabolism Reviews·M L RoseR G Thurman
Mar 4, 2005·Critical Reviews in Toxicology·Michelle L O'BrienHoward P Glauert
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D A WestR A Roberts
Jun 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H BesselinkA Brouwer
Feb 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Narci C TeohGeoffrey C Farrell
Aug 4, 2004·Toxicology and Applied Pharmacology·Karen G Calfee-MasonHoward P Glauert
Aug 30, 2005·Cancer Letters·Marcello Arsura, Lakita G Cavin
Mar 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Karen G Calfee-MasonHoward P Glauert
Jul 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jun LiHoward P Glauert
Oct 30, 2007·Toxicology and Applied Pharmacology·Job C TharappelHoward P Glauert
Jun 26, 2001·Toxicologic Pathology·C S ElangbamR M Lightfoot
May 8, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Courtney G WoodsIvan Rusyn
Jan 26, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Howard P GlauertBrett T Spear
Dec 5, 2017·Archives of Toxicology·J Christopher CortonJames E Klaunig

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