Treatment of recent-onset atrial fibrillation with quinidine and flecainide in Thoroughbred racehorses: 107 cases (1987-2014)

Journal of the American Veterinary Medical Association
Yuji TakahashiHajime Ohmura

Abstract

OBJECTIVE To compare the efficacy of quinidine and flecainide in treating naturally occurring, recent-onset atrial fibrillation (AF) in Thoroughbred racehorses. DESIGN Retrospective case series. ANIMALS 107 Thoroughbred racehorses. PROCEDURES Medical records of racehorses with AF that were treated with quinidine or flecainide between 1987 and 2014 were reviewed. Signalment, history, treatments, complications, and outcome data were collected. Horses were allocated to 2 groups according to the initial treatment: initial treatment with quinidine (group 1) or initial treatment with flecainide (group 2). Horses in group 2 that did not convert to sinus rhythm with flecainide were then administered quinidine (group 3). Complications, total quinidine dose, and duration of treatment were compared. Rates of conversion for horses treated with quinidine versus flecainide were also compared. RESULTS Overall rate of cardioversion was 91% (97/107). There was a significant difference in the rate of cardioversion for quinidine alone (91% [71/78]), compared with flecainide alone (41% [12/29]). In group 3, the conversion rate after the addition of quinidine treatment was 82% (14/17). Total quinidine dose and treatment duration did not differ sign...Continue Reading

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Citations

Aug 23, 2018·Journal of Veterinary Internal Medicine·Helena CarstensenRikke Buhl
Jan 21, 2021·The Veterinary Journal·Annelies DecloedtGunther van Loon
Feb 25, 2021·British Journal of Pharmacology·Arnela SaljicRikke Buhl
Sep 27, 2021·Equine Veterinary Journal·Antoine PremontKamalan Jeevaratnam

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