PMID: 9417448Jan 7, 1998Paper

Treatment of recurrent epistaxis in Rendu-Osler-Weber disease

HNO
J A WernerH Rudert

Abstract

Rendu-Osler-Weber disease is an autosomally dominant inherited disease which affects the connective tissue of blood vessels. The major symptom is recurrent epistaxis for which still exists no generally recommended treatment. Treatment modalities discussed in the literature include bilateral closure of the nostrils, brachytherapy, vessel embolization, hormone therapy, dermoplasties, as well as different kinds of laser therapies. Advantages and disadvantages of single treatment modalities are discussed. Dermoplasty and laser therapy seem to be the most suitable treatment procedures currently available for recurrent epistaxis in affected patients. Treatment carried out with the argon, KTP or ND:YAG laser has proven to be suitable as initial therapy. In most cases the additional use of long-term applications of a soft nasal ointment allows a lasting successful treatment. Our experiences show that dermoplasty should be reserved for cases with continued bleeding despite laser treatment but only rarely offers a long-term cure in the sense of a total recovery from epistaxis.

Citations

Dec 20, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Benedikt J FolzJochen A Werner
Apr 24, 2014·Oral and Maxillofacial Surgery·Marcus Stephan KriwalskyMartin Kunkel
Jul 25, 2015·British Journal of Haematology·Urban W GeisthoffUlrich Seyfert
Jul 22, 2016·Clinical and Experimental Otorhinolaryngology·Kornelia E C Wirsching, Thomas S Kühnel
May 19, 2006·Der Radiologe·M BlankenhornR R Tomczak
May 31, 2012·European Journal of Clinical Pharmacology·Sebastian FöllnerJens Schreiber
Apr 25, 2018·HNO·F Haubner, T Kühnel
May 21, 2020·Journal of Clinical Medicine·Urban GeisthoffFreya Droege
Oct 14, 2021·HNO·Kruthika ThangaveluUrban Geisthoff

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