Treatment of Recurrent Refractory Pediatric Pre-B Acute Lymphoblastic Leukemia Using Inotuzumab Ozogamicin Monotherapy Resulting in CD22 Antigen Expression Loss as a Mechanism of Therapy Resistance

Journal of Pediatric Hematology/oncology
Megan R PaulDennis J Kuo

Abstract

Inotuzumab ozogamicin is a novel antibody-drug conjugate that targets CD22, a common antigen on pre-B acute lymphoblastic leukemia cells. A 7-year-old boy with pre-B acute lymphoblastic leukemia in his second relapse was given 2 cycles of inotuzumab ozogamicin. He responded morphologically with a negative bone marrow evaluation. However, he relapsed in cycle 3 of therapy with a loss of CD22 expression on his lymphoblast population. To our knowledge, this is the first published case of CD22 expression loss as a mechanism of therapy resistance for inotuzumab ozogamicin.

References

Aug 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A RaetzUNKNOWN Children's Oncology Group Pilot Study
Mar 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anjali AdvaniLuis Fayad
May 9, 2013·Journal of Pediatric Hematology/oncology·Bettina ReismüllerUNKNOWN Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group
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Mar 14, 2017·Frontiers in Immunology·Maulik VyasElke Pogge von Strandmann

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Citations

Dec 8, 2019·Cancer Metastasis Reviews·Hiroto Inaba, Ching-Hon Pui
Feb 23, 2021·Journal of Extracellular Vesicles·Mark BarokHeikki Joensuu
Jun 7, 2021·Journal of Hematology & Oncology·Yurou ChuXin Wang
Mar 1, 2020·Annual Review of Cancer Biology·Kristopher R BosseJohn M Maris
Sep 2, 2021·Blood Advances·Paraskevi DiamantiAllison Blair

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Methods Mentioned

BETA
bone marrow aspiration
flow cytometry
chromosomal aberrations

Clinical Trials Mentioned

NCT02981628

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