PMID: 7083242Jun 1, 1982Paper

Treatment of refractory acute nonlymphocytic leukemia with a combination of pyrazofurin and cytarabine

Cancer Treatment Reports
H G KaplanA Fefer

Abstract

Six patients with refractory acute nonlymphocytic leukemia were treated with pyrazofurin (15 mg/m2) followed by cytarabine (100 mg/m2) every 12 hours for 6--21 days. All patients cleared their peripheral blood of blast cells but no complete remissions were achieved. Excessive toxicity to skin and mucous membranes was observed. In the doses used, this combination is too toxic for further use. Alternate treatment schedules should be explored.

Related Concepts

NSC 143095
Acute Disease
Antibiotics, Cytotoxic
Cytonal
Drug Administration Schedule
Drug Augmentation
Polychemotherapy
Leukemia
Ribonucleosides

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