Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jatin M VyasGregory K Robbins

Abstract

A patient with acquired immune deficiency syndrome presented with babesiosis 6 months after presumed tick exposure. Despite initial treatment with azithromycin and atovaquone, followed by quinine and clindamycin, he experienced an increasing parasite load. Finally, red blood cell exchange transfusion, anti-Babesia therapy, and the addition of atovaquone-proguanil to the treatment regimen led to symptomatic improvement and elimination of parasitemia. Low-level parasitemia recurred 20 weeks later and was eradicated by administration of atovaquone-proguanil monotherapy. Atovaquone-proguanil appears to have activity against babesiosis and should be studied as a potential therapy for patients with refractory babesiosis.

References

Jan 1, 1993·Journal of Clinical Apheresis·L MachtingerD Goldfinger
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Falagas, M S Klempner
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·D A Fidock, T E Wellems
Jul 17, 1998·The New England Journal of Medicine·P J KrauseD H Persing
May 29, 1999·Antimicrobial Agents and Chemotherapy·I K Srivastava, A B Vaidya
Nov 18, 2000·The New England Journal of Medicine·P J KrauseA Spielman
Jun 21, 2002·Transfusion Medicine Reviews·Vivien I Powell, Kathleen Grima
Aug 2, 2002·Expert Opinion on Pharmacotherapy·Louis M Weiss
Mar 6, 2004·Lancet·M Kent FrobergJohan S Bakken
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Domenico MavilioAnthony S Fauci
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary P WormserRobert B Nadelman

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Citations

Oct 12, 2010·Clinical Microbiology Reviews·J L N BarrattD Stark
Sep 4, 2009·Interdisciplinary Perspectives on Infectious Diseases·Edouard Vannier, Peter J Krause
Jun 21, 2011·The American Journal of Medicine·Kitsada WudhikarnSusan E Kline
Mar 18, 2009·Journal of Clinical Apheresis·Joshua SpaeteJoseph D Sweeney
Dec 3, 2015·Tropical Parasitology·Subhash Chandra ParijaHrudya Venugopal
Aug 30, 2008·Infectious Disease Clinics of North America·Edouard VannierPeter J Krause
Mar 27, 2010·FEMS Microbiology Reviews·Hany M Elsheikha, Naveed Ahmed Khan
Oct 22, 2016·Emerging Infectious Diseases·Meghan B BrennanGregory M Gauthier
Apr 10, 2020·Expert Review of Anti-infective Therapy·Robert P SmithPeter J Krause
Apr 21, 2020·The Journal of Infectious Diseases·Bumduuren TuvshintulgaIkuo Igarashi
Feb 17, 2019·Parasitology Research·Zetian ChenXiangye Liu
Aug 3, 2021·Transfusion Medicine Reviews·Toufic TannousJoseph D Sweeney

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