Treatment of refractory catatonic schizophrenia with low dose aripiprazole.

Annals of General Psychiatry
Tsuyoshi SasakiMasaomi Iyo

Abstract

This case is of 54-year-old female with catatonic schizophrenia, characterized by treatment resistance to the pharmacotherapy with olanzapine, risperidone, flunitrazepam, and ECT. Olanzapine and risperidone and flunitrazepam did not improve her catatonic and psychotic symptoms, and induced the extrapyramidal symptoms. The effects of ECT did not continue even for a month. However, the treatment with low-dose aripiprazole dramatically improved the patient's psychotic symptoms and extrapyramidal symptoms. The mechanisms underlying the effects of low-dose aripiprazole in this case remain unclear, but unlike other antipsychotics, aripiprazole is a dopamine D2 partial agonist. In this regard, our results suggest that aripiprazole has numerous advantages, especially in cases of stuporous catatonia and a defective general status.

References

Jul 2, 2003·The American Journal of Psychiatry·Michael Alan Taylor, Max Fink
Jun 21, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Filip Van Den EedeBernard G C Sabbe
Sep 9, 2006·Annals of General Psychiatry·Heath R PenlandRajesh R Tampi
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Pilar Lopez-GarciaRafael Gonzalez
Dec 12, 2007·The Journal of Neuropsychiatry and Clinical Neurosciences·Brendan T CarrollCamilo Muñoz
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Dec 9, 2009·Schizophrenia Bulletin·Patricia I Rosebush, Michael F Mazurek

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Citations

Sep 4, 2014·Case Reports in Psychiatry·Aaron J RobertoKyle A B Lapidus
Jun 20, 2015·Annals of General Psychiatry·Tsuyoshi Sasaki, Masaomi Iyo

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Methods Mentioned

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pharmacotherapy

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