Treatment of refractory donor-site seromas with percutaneous instillation of fibrin sealant

Plastic and Reconstructive Surgery
Charles E Butler

Abstract

Seromas at the flap donor site can occur following reconstructive surgery, and chronic seromas are particularly difficult to treat. Intraoperative use of fibrin sealant has been shown to enhance adherence of tissue surfaces and reduce postoperative fluid drainage. It was hypothesized that percutaneous instillation of fibrin sealant is effective for the postoperative treatment of refractory donor-site seromas. Four patients over a 3-year period developed refractory donor-site seromas that were treated with instillation of fibrin sealant. The thrombin concentration was diluted to 5 IU/ml to increase polymerization time. The seromas were completely aspirated, and 20 ml of fibrin sealant was instilled through a dual-lumen catheter. Seroma recurrence was evaluated by serial physical examinations. Results were compared with those of control patients (n = 26) with seromas that persisted at least 6 weeks postoperatively despite conservative therapy including serial aspirations and/or drain reinsertion. All study patients failed conservative therapy before fibrin sealant instillation, which was performed a mean of 6.1 weeks postoperatively. All four patients had immediate and complete resolution of their refractory seromas following a s...Continue Reading

References

Mar 1, 1990·Archives of Surgery·W H LindseyR F Morgan
Mar 1, 1987·The Journal of Surgical Research·P H JørgensenT T Andreassen
Nov 1, 1989·The Journal of Burn Care & Rehabilitation·R SaltzL O Vasconez
May 1, 1989·Plastic and Reconstructive Surgery·S A Slavin
Aug 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H Matras
Aug 1, 1982·The Thoracic and Cardiovascular Surgeon·H RedlH P Dinges
Jan 1, 1983·Aesthetic Plastic Surgery·F U Piechotta, I Flemming
Sep 1, 1983·Annals of Plastic Surgery·L S NichterM T Edgerton
Jan 1, 1995·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·F VaxmanJ F Grenier
Jul 1, 1994·British Journal of Plastic Surgery·D Marchac, G Sándor
May 1, 1993·The Journal of Burn Care & Rehabilitation·S Vedung, A Hedlung
Feb 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·G Marx, A Blankenfeld
Feb 15, 1996·The Journal of Surgical Research·R P SandersW D Spotnitz
Mar 1, 1997·Plastic and Reconstructive Surgery·D A KulberL Hoffman
Oct 6, 1997·The Journal of Burn Care & Rehabilitation·V McGillR Gamelli
Oct 27, 1998·Annals of Plastic Surgery·C A MarekD B Drake
Dec 5, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·F N GillyJ Vignal
Jan 23, 1999·Plastic and Reconstructive Surgery·R C BuckleyM A Brzezienski
Nov 1, 2002·Plastic and Reconstructive Surgery·Arun K GosainUNKNOWN Plastic Surgery Educational Foundation DATA Committee

❮ Previous
Next ❯

Citations

Nov 16, 2013·Current Problems in Surgery·Charles E ButlerMichael J Rosen
Nov 18, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·A S Ali-KhanJ Kenealy
Mar 19, 2015·Annals of Surgical Oncology·Lobna OuldamerGilles Body
Feb 25, 2015·Gynécologie, obstétrique & fertilité·A Trefoux-BourdetL Ouldamer
Jan 10, 2014·Annals of Plastic Surgery·Zachary M HurwitzRaymond M Dunn
Jul 3, 2008·Plastic and Reconstructive Surgery·Thomas W GilbertJ Peter Rubin
Jun 28, 2016·Plastic and Reconstructive Surgery·Jeffrey E JanisIbrahim Khansa
Aug 21, 2020·Langenbeck's Archives of Surgery·Andreas Lutz Heinrich GerkenJakob C Dobroschke
Feb 16, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Antonio Roberto da Rosa RezendeMarcus Vinicius Martins Collares
May 15, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Rieka TaghizadehEva M Weiler-Mithoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.