Treatment of refractory recurrent pericarditis

Journal of Cardiovascular Medicine
Massimo ImazioRita Trinchero


We report a difficult case of a 45-year-old woman with refractory recurrent pericarditis, who was treated with several different medical therapies, pericardial window, and pericardiectomy. This case suggests that more invasive diagnostic and therapeutic choices, such as pericardial window and pericardiectomy, should be carefully considered for possible side-effects and the risk of promoting further recurrences. Non-steroidal anti-inflammatory drugs and colchicine are first-choice drugs, whereas corticosteroids should be considered only in patients with a frequent crisis unresponsive to non-steroidal anti-inflammatory drugs, and by using proper dosage and a careful slow tapering. Patience and appropriate medical therapy are the keys to successful management. In true refractory cases, combination therapy with two or three drugs such as non-steroidal anti-inflammatory drugs, colchicine and corticosteroid may be considered before applying other more complex and less safe treatments. Immunosuppressive drugs and steroid sparing agents might be used, but it should be acknowledged that only weak evidence-based data support their use.


Aug 11, 1991·The Annals of Thoracic Surgery·P A DeValeriaB A Reitz
Feb 1, 1986·Journal of the American College of Cardiology·N O Fowler, A D Harbin
Jul 1, 1970·American Heart Journal·C H Asplen, H D Levine
May 4, 1968·British Medical Journal·J Robinson, W Brigden
Nov 1, 1995·Journal of the American College of Cardiology·R MarcolongoC Agostini
Aug 23, 2003·Journal of the American College of Cardiology·Marja RaatikkaEero V Jokinen
Dec 19, 2003·Journal of the American College of Cardiology·Massimo ImazioRita Trinchero
Mar 6, 2004·Lancet·Richard W TroughtonAllan L Klein
Mar 19, 2004·Journal of the American College of Cardiology·Massimo ImazioRita Trinchero
May 4, 2004·European Heart Journal·Bernhard MaischUNKNOWN Task Force on the Diagnosis and Management of Pricardial Diseases of the European Society of Cardiology
Oct 16, 2004·Heart·Jordi Soler-SolerGaietà Permanyer-Miralda
Nov 19, 2004·The New England Journal of Medicine·Richard A Lange, L David Hillis
Feb 26, 2005·Journal of Cardiac Failure·Ralph Shabetai
Mar 10, 2005·European Heart Journal·Bernhard Maisch
Aug 30, 2005·The American Journal of Cardiology·Massimo ImazioRita Trinchero
Oct 6, 2005·European Heart Journal·Antonio BrucatoDavid H Spodick
Oct 18, 2005·European Heart Journal·Iwan C C van der Horst, Felix Zijlstra
Mar 29, 2006·Circulation·William C Little, Gregory L Freeman
Mar 29, 2006·Archives of Internal Medicine·Antonio BrucatoDavid H Spodick

❮ Previous
Next ❯


May 1, 1994·The American Journal of Cardiology·Y AdlerY Shoenfeld
Oct 16, 2001·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K Y OhG K Danielson
Oct 7, 2009·Future Cardiology·Massimo ImazioYehuda Adler
Nov 1, 2007·Future Cardiology·Massimo Imazio, Rita Trinchero
Jan 9, 2016·The American Journal of Cardiology·Dor LotanYehuda Adler
Jan 13, 2017·Pharmacotherapy·Nicholas C SchwierMarie L Davies
Aug 15, 2018·Expert Review of Cardiovascular Therapy·Alessandro Galluzzo, Massimo Imazio
Feb 24, 2010·Circulation·Massimo ImazioYehuda Adler
May 31, 2012·Journal of Cardiovascular Medicine·Alessandra BuiattiGianfranco Sinagra
Oct 27, 2012·Expert Review of Cardiovascular Therapy·Massimo Imazio
Apr 26, 2013·Journal of Cardiovascular Medicine·Alessandro BiffiUNKNOWN Italian Society of Sports Cardiology and Italian Sports Medicine Federation
Apr 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Sai KongFeng-Juan Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved