PMID: 2495317May 1, 1989Paper

Treatment of reperfusion injury with intracoronary calcium channel antagonists and reduced coronary free calcium concentration in regionally ischemic, reperfused porcine hearts

Journal of the American College of Cardiology
H H KleinH Kreuzer

Abstract

The effect of intracoronary diltiazem, EGTA (ethylene-bis-(beta-aminomethylether)-N,N'-tetraacetic acid), nifedipine, verapamil and isotonic saline solution as placebo on reperfusion injury was investigated in regionally ischemic, reperfused porcine hearts. The left anterior descending coronary artery was distally occluded for 45 min and was reperfused for 3 days. Intracoronary infusion was started immediately before reperfusion and continued during 45 min of reperfusion. Infarct size was determined as the ratio of infarcted (tetrazolium stain) to ischemic myocardium (dye technique). Regional systolic shortening was assessed by sonomicrometry. Apart from left ventricular end-diastolic pressure before ischemia and during 45 min of reperfusion, global hemodynamic values in the five treatment groups did not differ; in particular, calculated left ventricular oxygen consumption before and during ischemia was equally low. Intracoronary EGTA decreased coronary venous free calcium concentration to about 70% of baseline value. Infarct size was reduced from 76 +/- 10% (control group, n = 8) to 60 +/- 10% (p less than 0.01) by intracoronary diltiazem (n = 8) and to 55 +/- 15% (p less than 0.01) by intracoronary EGTA (n = 8). Insignificant...Continue Reading

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Citations

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May 3, 2012·Annals of the New York Academy of Sciences·David Sanz-RosaBorja Ibanez
Mar 20, 2010·Journal of the American College of Cardiology·Nathaniel Reichek, Kambiz Parcham-Azad
Nov 26, 2010·International Journal of Cardiology·Borja IbanezJuan J Badimon
May 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiju HeYanhong Liao
Mar 29, 2013·European Heart Journal·Georg M FröhlichDerek J Hausenloy
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Dec 13, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Roberto FerrariGianluca Campo
Jan 1, 1991·Basic Research in Cardiology·H H KleinP Schuff-Werner
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