Treatment of restless legs syndrome with the selective AMPA receptor antagonist perampanel

Sleep Medicine
Diego Garcia-BorregueroJuan Jose Granizo

Abstract

Perampanel is a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) antagonist that has been approved for the treatment of partial seizures. Here we report on the first open study evaluating its efficacy in idiopathic restless legs syndrome (RLS). The study was designed as a prospective two-month open trial. Twenty-two previously untreated patients diagnosed with idiopathic RLS began treatment with 2 mg perampanel, which was increased to 4 mg at week four if clinically necessary. Multiple Suggested Immobilization Tests (mSITs) followed by polysomnography were performed at baseline and at week eight. Severity ratings were performed every two weeks by means of the IRLS scale, and Clinical Global Index (CGI) subscale. The main endpoint was therapeutic response, defined as a 50% improvement in IRLS total score. Twenty patients completed the study. During the 8-week treatment period, the IRLS score improved from a mean (±standard deviation (SD)) 23.7 ± 4.2 to 11.5 ± 5.3. Twelve of 20 patients were full responders (improvement 50% in IRLS total score), and four responded partially. The mean effective dose of perampanel at the end of treatment was 3.8 mg/day. Treatment with perampanel also re...Continue Reading

Citations

Aug 11, 2018·Expert Review of Neurotherapeutics·Marco ZucconiLuigi Ferini-Strambi
May 7, 2020·Movement Disorders Clinical Practice·Adrian HandforthRodger J Elble
Aug 7, 2020·Continuum : Lifelong Learning in Neurology·Celia Garcia-MaloDiego Garcia-Borreguero
May 28, 2020·International Journal of Environmental Research and Public Health·Giuseppe DidatoPaola Lanteri
Feb 23, 2020·Seizure : the Journal of the British Epilepsy Association·Rodrigo RocamoraAlessandro Principe
Feb 3, 2021·Pediatric Pulmonology·Lourdes M DelRossoRaffaele Ferri
Apr 22, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas R GossardErik K St Louis
Apr 6, 2020·Chest·Sofía Romero-PeraltaDiego García-Borreguero
May 15, 2021·Sleep Medicine Clinics·Celia Garcia-MaloIrene Cano-Pumarega
May 15, 2021·Sleep Medicine Clinics·Laura M Botta PDiego Garcia-Borreguero
Jul 6, 2021·Mayo Clinic Proceedings·Michael H SilberUNKNOWN Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation
Nov 5, 2021·Nature Reviews. Disease Primers·Mauro ManconiYves Dauvilliers

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