Treatment of retroperitoneal sarcoma: current standards and new developments

Current Opinion in Oncology
Winan J van HoudtRobin L Jones

Abstract

Retroperitoneal sarcomas are rare tumors and with complex treatment. In this manuscript we give an overview of current standards in treatment of this disease and discuss new developments. Surgery with complete resection of the primary tumor is still the only curative modality. The role of preoperative radiotherapy is not clear and is currently being investigated in a clinical trial. Neo-adjuvant chemotherapy is not the standard of care but can be considered occasionally when complete resection is uncertain. Local and distant recurrent disease carries a dismal prognosis, although long-term survival can be achieved. Liposarcomas tend to recur locally, whereas distant recurrences are more often seen in leiomyosarcoma and other subtypes. Outcome improves when patients are treated in high volume sarcoma centers. In the metastatic setting, newer systemic agents have recently been approved. Treatment of retroperitoneal sarcomas is complex and all patients should be treated in multidisciplinary sarcoma centers. Increasing international collaboration of expert centers in sharing expertise and performing clinical trials might lead to better treatment and improved survival.

References

Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter W T PistersShreyaskumar R Patel
Nov 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robin L JonesIan R Judson
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Alberto BossiBianca Vanstraelen
May 25, 2007·Annals of Surgery·Juan C GutierrezLeonidas G Koniaris
Jun 3, 2008·The Surgical Clinics of North America·Matthew T HuemanNita Ahuja
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvie BonvalotAgnès Laplanche
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro GronchiPaolo Giovanni Casali
Mar 23, 2010·The British Journal of Surgery·D C StraussJ M Thomas
Apr 8, 2011·The Journal of Surgical Research·Warren H TsengRobert J Canter
Mar 1, 2012·Surgical Oncology Clinics of North America·Carol J Swallow, Charles N Catton
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark A DicksonGary K Schwartz
Feb 15, 2014·Expert Review of Anticancer Therapy·Aisha B MiahDirk C Strauss
Mar 13, 2014·The Lancet Oncology·Ian JudsonUNKNOWN European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Apr 11, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret von MehrenUNKNOWN National Comprehensive Cancer Network
Aug 15, 2014·Annals of Surgery·Murray F BrennanSamuel Singer
Jan 30, 2015·Clinical Sarcoma Research·Roberta SanfilippoPaolo Giovanni Casali
Sep 16, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George D DemetriShreyaskumar R Patel
Sep 4, 2016·Surgical Oncology Clinics of North America·Rebecca A GladdyCharles N Catton
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher W RyanPatrick Schöffski
Nov 20, 2016·Cancer·David Berger-Richardson, Carol J Swallow
Mar 24, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·S J FordA Gronchi

❮ Previous
Next ❯

Citations

Jul 4, 2017·Journal of Surgical Oncology·William W Tseng, Alessandro Gronchi
Feb 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG)
Nov 12, 2017·Journal of Surgical Oncology·William W TsengAlessandro Gronchi
Oct 18, 2018·CA: a Cancer Journal for Clinicians·David A MahviChandrajit P Raut
Jul 19, 2018·ESMO Open·Anna Maria FrezzaPaolo G Casali
Apr 18, 2020·Digestive Diseases and Sciences·L SerafiniV Tonini
Oct 13, 2018·World Journal of Surgical Oncology·Michael J NathensonEdward Sausville
Dec 12, 2017·Journal of Surgical Oncology·Oluwadamilola TeniolaBehrang Amini
Jul 31, 2018·Japanese Journal of Clinical Oncology·Ruping ZhaoShenglin Ma
Dec 22, 2017·Journal of Surgical Oncology·John T Mullen, Winan van Houdt
Nov 22, 2019·World Journal of Clinical Cases·Zisis TouloumisJohn Griniatsos
Jan 25, 2020·Sarcoma·Rosa Álvarez ÁlvarezClaudia María Valverde
Oct 31, 2020·Frontiers in Oncology·Ya-Ling LiBing Song
Dec 15, 2020·BMJ Case Reports·Muhamed TajudeenAmaranathan Anandhi
Nov 18, 2021·Khirurgiia·S G AfanasyevI G Frolova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.