Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience.

Chest
Christopher F BarnettReda E Girgis

Abstract

Pulmonary hypertension (PH) is a common complication of sarcoidosis that is associated with increased mortality. The pathogenesis of PH in sarcoidosis is uncertain, and the role of pulmonary arterial hypertension (PAH)-specific therapies remains to be determined. We conducted a retrospective study of patients with sarcoidosis and PH at two referral centers. New York Heart Association (NYHA) functional class, exercise capacity, hemodynamic data, pulmonary function tests, and survival were collected and analyzed. Twenty-two sarcoidosis patients treated with PAH-specific therapies were identified. After a median of 11 months of follow-up, NYHA class was improved in nine subjects. Mean 6-min walk distance (n = 18) increased by 59 m (p = 0.032). Patients with a higher FVC experienced a greater increment in exercise capacity. Among 12 patients with follow-up hemodynamic data, mean pulmonary artery pressure was reduced from 48.5 +/- 4.3 to 39.4 +/- 2.8 mm Hg (p = 0.008). The 1- and 3-year transplant-free survival rates were 90% and 74%, respectively. PAH-specific therapy may improve functional class, exercise capacity, and hemodynamics in PH associated with sarcoidosis. Prospective, controlled trials of PAH therapies for sarcoidosis a...Continue Reading

References

Jan 1, 1985·Catheterization and Cardiovascular Diagnosis·A ManglaS Saddekni
Nov 1, 1985·Archives of Internal Medicine·R J Barst, S J Ratner
May 1, 1982·Postgraduate Medical Journal·J DaviesJ F Goodwin
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Jul 26, 2002·The New England Journal of Medicine·Brett N Pereira, Sundeep Salvi
Oct 2, 2002·Lancet·Hossein Ardeschir GhofraniFriedrich Grimminger
Jun 15, 2004·Journal of the American College of Cardiology·Gerald SimonneauAlfred Fishman
May 3, 2005·The European Respiratory Journal·A F ShorrS D Nathan
Nov 18, 2005·The New England Journal of Medicine·Nazzareno GalièUNKNOWN Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group
Apr 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T M EganF L Grover
Mar 7, 2007·Clinics in Chest Medicine·Reda E Girgis, Stephen C Mathai
May 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·Aniket PuriSudhir S Kushwaha
Jul 13, 2007·Chest·Robert P BaughmanElyse E Lower
Oct 18, 2007·Current Opinion in Pulmonary Medicine·Hidenobu ShigemitsuOm P Sharma
Mar 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nils MilmanJørn Carlsen

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Citations

Jul 14, 2011·Nature Reviews. Rheumatology·Edward S Chen, David R Moller
Aug 6, 2013·Current Opinion in Pulmonary Medicine·Francis C Cordova, Gilbert D'Alonzo
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tamera J CorteStephen J Wort
Oct 25, 2012·Pulmonary Medicine·Iraklis TsangarisStylianos E Orfanos
Nov 3, 2010·American Journal of Respiratory and Critical Care Medicine·Robert P BaughmanMarc A Judson
Jun 5, 2012·American Journal of Respiratory and Critical Care Medicine·Paul M Hassoun, Serge Adnot
Jun 7, 2013·Annals of Thoracic Medicine·Esam H AlhamadSuliman A Alhomida
May 15, 2013·Future Cardiology·Julio D DuarteRoberto F Machado
Jul 16, 2014·Current Opinion in Pulmonary Medicine·Marc A Judson, Robert P Baughman
Jul 22, 2014·Current Opinion in Pulmonary Medicine·Dominique ValeyreJean-François Bernaudin
Apr 23, 2011·Expert Review of Respiratory Medicine·Oksana A Shlobin, Steven D Nathan
Nov 26, 2013·Clinics in Chest Medicine·Tim Lahm, Murali M Chakinala
Jan 7, 2011·Chest·Adam S Morgenthau, Michael C Iannuzzi
Jun 6, 2009·Chest·Gustavo A Heresi, Raed A Dweik
Sep 27, 2012·Progress in Cardiovascular Diseases·Hooman D PoorSean M Studer
May 23, 2012·La Presse médicale·Hilario NunesDominique Valeyre
May 4, 2011·La Presse médicale·Vincent CottinJean-François Cordier
Dec 16, 2010·La Revue de médecine interne·V Cottin
Apr 1, 2010·Archivos de bronconeumología·Luis Alberto Ruiz Iturriaga, Adolfo Baloira
Dec 5, 2009·La Presse médicale·Hilario NunesDominique Valeyre
Jul 25, 2015·The Lancet. Respiratory Medicine·Robert P Baughman, Jan C Grutters
Nov 26, 2015·Clinics in Chest Medicine·Robert P BaughmanSteven Nathan
Jan 18, 2014·Journal of Internal Medicine·A Eklund, R M du Bois
Jul 16, 2015·Current Opinion in Pulmonary Medicine·Robert P BaughmanLesley Ann Saketkoo
May 21, 2015·Clinical Reviews in Allergy & Immunology·Robert P Baughman, Elyse E Lower
Mar 10, 2016·Expert Review of Respiratory Medicine·Ying ZhouRobert P Baughman
Apr 13, 2012·Respiratory Medicine·Marc A Judson
Dec 21, 2013·Journal of the American College of Cardiology·Werner SeegerJean-Luc Vachiéry
Aug 16, 2014·La Presse médicale·Vincent Cottin
May 20, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M P HuitemaM C Post
Aug 11, 2016·Annals of the American Thoracic Society·Robert P BaughmanGerhard Wolff
Aug 25, 2016·Chest·Oksana A ShlobinSteven D Nathan
Jul 19, 2014·Therapeutic Advances in Respiratory Disease·Emily N AminElliott D Crouser
Nov 19, 2010·Chronic Respiratory Disease·Sally de Boer, Margaret Wilsher
Jul 30, 2009·Therapeutic Advances in Respiratory Disease·Georgia G PitsiouIoannis Stanopoulos
May 11, 2013·Pulmonary Circulation·Paul R ForfiaSusan E Wiegers
Oct 29, 2011·Pulmonary Circulation·M Patricia GeorgeJoseph M Pilewski
Oct 27, 2017·Annals of the American Thoracic Society·William H SauerWalter Royal
Jan 17, 2017·Pulmonary Circulation·H J FordJ F Donohue
Jan 4, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·George A MargaritopoulosAthol U Wells
Dec 14, 2018·The European Respiratory Journal·Steven D NathanWerner Seeger
Oct 21, 2017·The European Respiratory Journal·Robert P Baughman, Oksana A Shlobin
Oct 21, 2017·The European Respiratory Journal·Athénaïs BouclyLaurent Savale
Jul 26, 2019·Current Opinion in Pulmonary Medicine·Robert P Baughman, Athol Wells

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