PMID: 11334194May 4, 2001Paper

Treatment of sepsis in cardiac surgery: role of immunoglobulins

Perfusion
A SablotzkiI Friedrich

Abstract

Cardiopulmonary bypass (CPB) is associated with an injury that may cause pathophysiological changes such as systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and mediator-induced multiorgan failure. Systemic endotoxinaemia, release of proinflammatory cytokines, and interactions between neutrophils and endothelium have been reported to correlate with a high incidence of organ dysfunction, infection and sepsis following cardiac surgery. This review discusses the dysregulation of the immune response as a major reason for the higher susceptibility to infections following cardiac surgery, various treatment strategies to reduce CPB-induced inflammation, and especially the prophylactic use of immunoglobulins in cardiac surgery.

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Citations

Nov 8, 2011·Infectious Disease Clinics of North America·Jennifer L Hsu, Nasia Safdar
May 31, 2013·Perfusion·M Zakkar, R Kanagasabay
Oct 18, 2003·Anesthesiology Clinics of North America·Tatjana Pintar, Charles D Collard
Mar 21, 2002·Hospital Medicine·Susanne HerroederMarkus W Hollmann

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