PMID: 11925534Apr 2, 2002Paper

Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
M A González-MolesSalvador Gonzalez-Moles

Abstract

We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions. Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excellent (75%), good (50%), poor (<50%), or failed. The pain and ulceration totally disappeared in 93.3% of cases and 90% reported a full recovery in their daily life activities. Atrophy response was complete in 28.5%, excellent in 60.7%, and good in 3.5%. Two patients showed no response to the treatment. Five patients suffered mild adverse effects (moon face and hirsutism) between week 4 and week 6 of treatment, which were speedily reversed by reducing the frequency of mouthwash. Clobetasol mouthwash is a safe and efficacious option for the treatment of severe oral erosive lesions.

References

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Citations

Nov 5, 2013·International Journal of Pharmaceutics·Ehab R BendasMohamed A A Kassem
Jun 6, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Miguel Angel Gonzalez-MolesManuel Bravo
Jan 2, 2008·Journal of Periodontology·Lucio Lo RussoGiuseppina Campisi
Dec 25, 2008·Journal of Oral Science·Kobkan Thongprasom, Kittipong Dhanuthai
Nov 28, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Gül Soylu Özler
Nov 7, 2009·Minerva stomatologica·M Carrozzo, R Thorpe
Feb 22, 2012·The American Journal of Medicine·Chuanxia LiuHongmei Zhou
Jul 1, 2008·Acta otorrinolaringológica española·Diana Quijano, Mauricio Rodríguez
Aug 27, 2005·The British Journal of Dermatology·M R AlidaeeS Z Ghodsi
Feb 27, 2008·Oral Diseases·M A Gonzalez-MolesJ A Gil-Montoya
Jan 8, 2009·International Journal of Dermatology·Michelle Pramick, S Elizabeth Whitmore
Jan 15, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M CarboneS Gandolfo
Jan 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R GuigliaM D'Angelo
Jan 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·M A Gonzalez-MolesA Bascones-Martinez
Jan 26, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Chuang, A J Langone
Feb 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M A Gonzalez-Moles, C Scully
Sep 29, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Elena M VaroniGiovanni Lodi
Mar 20, 2010·Clinical Transplantation·Josep M CampistolEggert Stockfleth
Jul 23, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Giovanni LodiKobkan Thongprasom
Jan 5, 2006·Lasers in Surgery and Medicine·Farzane AghahosseiniJalil Momen Beitollahi
Jun 29, 2015·Autoimmunity Reviews·Mayson B MustafaCassian Sitaru
Aug 18, 2012·Blood·Nathaniel TreisterLeslie Lehmann
Jan 18, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Young Chan LeeYoung Gyu Eun
Jan 14, 2017·Expert Opinion on Pharmacotherapy·Yehuda ZadikMichael Y Shapira
Aug 28, 2015·Brazilian Dental Journal·Fábio Renato Manzolli LeiteAdriana Etges
Sep 29, 2009·Brazilian Dental Journal·Ana Carolina Fragoso MottaDante Antonio Migliari
Nov 10, 2017·Oral Diseases·M A Gonzalez-MolesJ A Gil-Montoya
Mar 29, 2019·Journal of Materials Science. Materials in Medicine·Arash Ghalayani EsfahaniLuigi De Nardo
Jul 3, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H Husein-ElAhmedM Steinhoff
Sep 26, 2017·Therapeutic Delivery·Viviana De CaroLibero Italo Giannola
Jun 6, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M CarboneS Gandolfo
Jan 1, 2010·JBI Library of Systematic Reviews·Ruo-Ping HanShu Chin Chiu

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