Treatment of severe depression with the selective serotonin reuptake inhibitors

Depression and Anxiety
A F Schatzberg

Abstract

The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies in the severely depressed patient. A limited number of trials have attempted to address this issue. This review assesses 16 controlled studies of SSRIs in severe depression. The findings from a majority of studies found the SSRIs to be superior to placebo and as effective as but better tolerated than the tricyclic antidepressants (TCAs) in severely depressed patients. Although future studies are needed to corroborate and elaborate on these data, studies still support the use of SSRIs in this patient population.

Citations

Apr 29, 2005·International Journal of Clinical Practice·P-M LlorcaP Verpillat
Feb 9, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Latif MoradveisiArnoud Arntz
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·F Benazzi
Mar 24, 2009·Depression and Anxiety·David W MorrisA John Rush
Aug 13, 2002·Journal of Clinical Psychopharmacology·Vittorino AndreoliMarcio Versiani
Feb 13, 2007·International Clinical Psychopharmacology·Bruno FantinoJean-Paul Auray
Mar 29, 2019·The Journal of Nervous and Mental Disease·Mark Zimmerman
Nov 1, 2017·The International Journal of Neuropsychopharmacology·Gabriele Sachs, Andreas Erfurth

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