Treatment of severe, disabling spasticity with continuous intrathecal baclofen therapy following acquired brain injury: the experience of a tertiary institution in Singapore

Singapore Medical Journal
Zhe Min WangKaren Sui Geok Chua

Abstract

Intrathecal baclofen (ITB) therapy is a proven, effective treatment for disabling cortical spasticity. We describe the first local series of five patients with acquired brain injury (ABI) who received ITB and were followed up for 63.8 months. A retrospective review of medical and rehabilitation records of patients who received ITB therapy was carried out. Data studied included baseline demographic and injury variables, implantation data, spasticity and function, ITB dosage over time and complications. From 2006 to 2010, a total of five patients received ITB therapy via implanted pumps about 39.4 months after ABI. Four out of five patients experienced significant reductions in their lower limb spasticity scores and improvements in global function and dependency. One patient had minor adverse events associated with baclofen-related sedation. The mean ITB dose at one year was 182.7 ± 65.6 mcg/day. Our preliminary study showed encouraging long-term outcomes and safety for ITB therapy after ABI-related intractable spasticity. Individual ITB responses over time were variable, with gender differences. The outcomes experienced by our centre were comparable to those in the general ABI population, supporting the efficacy of ITB therapy f...Continue Reading

References

Mar 20, 1991·JAMA : the Journal of the American Medical Association·A L AlbrightJ Singletary
Jun 8, 1989·The New England Journal of Medicine·R D PennJ S Kroin
Feb 1, 1995·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P NanceD Fewer
Nov 24, 1993·JAMA : the Journal of the American Medical Association·A L AlbrightJ Janosky
Sep 17, 1999·Archives of Physical Medicine and Rehabilitation·J M GregsonC L Watkins
Mar 1, 2000·Journal of Child Neurology·R GilmartinJ Nadell
Mar 10, 2001·Archives of Physical Medicine and Rehabilitation·J M MeythalerM N Hadley
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·J M MeythalerM N Hadley
Dec 11, 2002·Archives of Physical Medicine and Rehabilitation·Nancy A MurphyCharles Hoff
Feb 21, 2003·Journal of Neurosurgery·A Leland AlbrightJohn F McLaughlin
Oct 3, 2003·Topics in Stroke Rehabilitation·G E Francisco
Mar 21, 2007·Acta Neurochirurgica. Supplement·T TairaT Hori
Feb 21, 2009·Neurorehabilitation and Neural Repair·D BensmailA Beresniak
Sep 21, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Neil HaranhalliJonathan Roth
Apr 1, 2000·Neuromodulation : Journal of the International Neuromodulation Society·A M Avellino, J D Loeser
Aug 28, 2013·Developmental Neurorehabilitation·Matthias WalterAndreas Meyer-Heim
Dec 20, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Konstantinos MargetisDamianos E Sakas
Dec 21, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Sunjay N MathurChristina M Marciniak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.