Treatment of slow/no-reflow phenomenon with intracoronary nitroprusside injection in primary coronary intervention for acute myocardial infarction

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Huang-Joe WangJui-Sung Hung

Abstract

Slow/no-reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) and is associated with a poor prognosis. From January 2002 to November 2002, 11 of the 70 consecutive patients with ST elevation AMI who were subjected to primary PCI using balloon angioplasty and/or stenting developed slow/no-reflow phenomenon (TIMI 1 flow in 2, TIMI 2 in 8, and TIMI 2.5 in 1). They were 10 men and 1 woman, aged 64 +/- 11 years (range, 46-81). The culprit vessels were six in the left anterior descending coronary artery, three in the right coronary artery, one in the left circumflex coronary artery, and one in saphenous vein graft. Multiple bolus doses (100 microg) of nitroprusside were injected into the index artery through the guiding catheter using a 3 ml syringe until the TIMI flow grade improved by at least one grade or the systolic pressure decline below 80 mm Hg (one patient). The total drug dose varied from 100 to 700 microg. Following the drug treatment, angiographic TIMI flow grade improved by at least one grade in 9 (82%) of the 11 patients (P = 0.007). The TIMI frame counts significantly decreased from 36 +/- 17 frame counts to 16 +/- 11 frame counts (P =...Continue Reading

References

Apr 15, 1995·The American Journal of Cardiology·K M AbboR D Safian
Apr 15, 1995·The American Journal of Cardiology·F J WeyrensM R Mooney
Apr 1, 1997·Plastic and Reconstructive Surgery·W Z WangJ Barker
Nov 5, 1997·Catheterization and Cardiovascular Diagnosis·D RawitscherT Feldman
Dec 24, 1998·Catheterization and Cardiovascular Diagnosis·T A FischellA Kloostra
Feb 17, 1999·Journal of Molecular and Cellular Cardiology·J B GavinS G Edgar
Sep 6, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A R AssaliO R Rosales
Feb 6, 2002·Circulation·Shereif H Rezkalla, Robert A Kloner
Nov 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kimberly A SkeldingWilliam W O'Neill
Nov 28, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gerald S WernerHans R Figulla
Oct 1, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Lloyd W KleinUNKNOWN Interventional Cardiology Committee of the Society of Cardiac Angiography and Interventions

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Citations

Sep 27, 2008·Journal of Thrombosis and Thrombolysis·Vijayalakshmi KunadianC Michael Gibson
Jul 7, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Makoto UtsunomiyaMasato Nakamura
Jan 1, 2014·Journal of Vascular Surgery·Seiichi HiramoriAtsushi Tosaka
Jun 30, 2011·Journal of Molecular and Cellular Cardiology·Bryan G Schwartz, Robert A Kloner
Jul 21, 2010·The American Journal of Cardiology·Aslan T Turer, Joseph A Hill
Dec 8, 2009·Cardiology Clinics·Sameer MehtaEsther Falcão
Jul 8, 2015·Cardiovascular Drugs and Therapy·George KassimisAdrian P Banning
Feb 4, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·William Wilson, David Eccleston
Jul 4, 2007·Expert Review of Cardiovascular Therapy·William J van Gaal, Adrian P Banning
Mar 17, 2005·European Heart Journal·Sigmund SilberUNKNOWN Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology
Oct 13, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Raymond I HuangMichael P Savage
May 2, 2008·Acute Cardiac Care·Kaeng W Lee, Michael S Norell
Aug 12, 2010·Acute Cardiac Care·Giampaolo NiccoliFilippo Crea
May 16, 2018·Heart·Sri Raveen Kandan, Thomas William Johnson
May 25, 2021·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Gagan KaurRamdas G Pai
Sep 4, 2021·Indian Heart Journal·Rakesh YadavGeetika Yadav

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