Oct 24, 2019

Treatment of soil-transmitted helminth infections in pregnancy: a systematic review and meta-analysis of maternal outcomes

Journal of Travel Medicine
Rachel LauAndrea K Boggild

Abstract

Gestational helminth infections are correlated to adverse outcomes including maternal anaemia; as such, treatment is recommended. However, little published high-quality data exist around the efficacy, safety and tolerability of anti-helminthics in pregnancy. We therefore conducted a systematic review and synthesized the available data on maternal outcomes following gestational treatment of intestinal nematodes to help guide clinical decision-making. Five electronic databases were searched for studies reporting the efficacy, safety or tolerability of anti-helminthic drugs for gestational treatment of intestinal nematodes. Studies were systematically screened followed by data extraction. Trial quality was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. We conducted a narrative synthesis followed by meta-analyses using random effects models as appropriate. Data were summarized using qualitative and quantitative measures for specific parasitic infections as well as efficacy and safety of anti-parasitic agents. Outcomes of interest included maternal anaemia, minor adverse outcomes, pregnancy loss, pre-mature delivery, prevalence of infection and cure rate. Twenty-three studies were incl...Continue Reading

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Mentioned in this Paper

Study
Vulnerable Populations
Antineoplastic Agents
Decision Making
Meta Analysis (Statistical Procedure)
Trichocephalus
Hookworms
Albendazole
Ivermectin
Adverse Effects

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