PMID: 7589392Jul 1, 1995

Treatment of steroid-dependent bronchial asthma with cyclosporin

The European Respiratory Journal
E NizankowskaA Szczeklik

Abstract

The treatment of chronic severe asthma is unsatisfactory for many patients. The aim of the study was to determine the effects of treatment of steroid-dependent asthma with cyclosporin. We performed a double-blind, placebo-controlled, randomized, parallel group trial on the effect of cyclosporin on pulmonary function, asthma severity and tapering of prednisone in 34 steroid-dependent asthmatics (mean oral prednisone dose: 16 mg.day-1). The study consisted of: 1) baseline period (12 weeks); 2) experimental period divided into two parts: Part I (12 weeks) cyclosporin or placebo treatment; Part II (22 weeks) cyclosporin or placebo treatment and oral prednisone reduction; and 3) follow-up observation (8 weeks). Asthma symptoms score, pulmonary function tests (daily peak expiratory flow (PEF) and bi-weekly forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximal mid-expiratory flow (MEF50), biochemical profile and blood cyclosporin levels were monitored throughout the study. Following cyclosporin administration, a slight beneficial effect on some subjective parameters of asthma severity was observed. At the same time, no beneficial effect on pulmonary function was noted. The time trends analysis of mean ...Continue Reading

References

Mar 31, 2009·European Journal of Internal Medicine·Riccardo Polosa, Giuseppe Trifoglio Benfatto
Feb 4, 1999·Advances in Internal Medicine·A Deykin, E Israel
Oct 19, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Inderpal Randhawa, William B Klaustermeyer
Jul 25, 2003·Pulmonary Pharmacology & Therapeutics·Gaetano Caramori, Ian Adcock
Jul 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J Barnes
Aug 24, 1999·Thorax·K F Chung, P J Barnes
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·B E GilbertW L Eschenbacher
Jan 1, 2010·Journal of Asthma and Allergy·Jaymin Morjaria, Riccardo Polosa
Dec 13, 2005·Treatments in Respiratory Medicine·E H Bel, Anneke ten Brinke
Jul 11, 2000·Clinical and Experimental Immunology·K RafiqS W Van Gool
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C In 't VeenE H Bel
Apr 1, 2003·Expert Opinion on Investigational Drugs·Jens W Eckstein, John Fung
Dec 1, 2001·Expert Opinion on Biological Therapy·K BlümchenE Hamelmann
Jan 23, 2016·Clinical Reviews in Allergy & Immunology·Stephanie S Eng, Magee L DeFelice
Aug 30, 2012·Clinics in Chest Medicine·A BourdinP Chanez
Apr 10, 2003·Chest·Alexander S Niven, Gregory Argyros
Oct 30, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Navarro MerinoGrupo de Trabajo Asma Infantil de la Sociedad Española de Neumología Pediátrica
Apr 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Satomi OnoueShizuo Yamada
Nov 6, 2007·La Presse médicale·M HumbertP Chanez
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K E S PlathB F Gibbs
Nov 22, 2007·Internal Medicine Journal·Riccardo Polosa
Aug 6, 2005·Pharmacology & Therapeutics·Michelle M Epstein
Jan 8, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satomi Onoue
Oct 8, 1998·Chemical Immunology·A B Kay
May 23, 2006·Respiratory Medicine·Stephen P PetersColin Reisner
Nov 5, 2013·Revue des maladies respiratoires·J CharriotA Bourdin
Nov 18, 2008·Respiratory Medicine·Riccardo Polosa, Jaymin Morjaria
Jun 17, 2016·International Forum of Allergy & Rhinology·Yeon-Hee JooSang-Wook Kim
Sep 17, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hiroki SuzukiSatomi Onoue
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Nadège RobertJames M Wright
Jun 19, 2001·The Cochrane Database of Systematic Reviews·D J EvansD M Geddes
Dec 10, 1999·Nature·P J Barnes
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·H S Park
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Chris J Corrigan

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