Treatment of subcutaneous tumor with adoptively transferred T cells

Cellular Immunology
L PengJ C Krauss

Abstract

Adoptive immunotherapy with T cells directed at tumor antigens has been demonstrated to result in the regression of malignant tumors in humans. These encouraging results have prompted the further exploration of parameters necessary to treat tumor in various locations in animal models. We have demonstrated that T cells that are sensitized to tumor antigens and then ex vivo cultured are capable of eradicating pulmonary metastases. In this report, we demonstrate that these T cells are capable of eliminating subcutaneous tumor deposits. Critical to the successful treatment of subcutaneous tumor was treatment with a large number of adoptively transferred T cells and pretreatment of the mice with irradiation. The transfer of T cells from tumor-bearing mice into irradiated mice failed to inhibit the therapeutic effect of ex vivo cultured T cells, suggesting that irradiation was not acting only as an immunosuppressant. Irradiation resulted in increased expression of the F4/80 and 33D1 epitopes on antigen-presenting cells within the tumor. The therapeutic effect of the adoptively transferred T cells was eliminated if either CD4 cells or CD8 cells were depleted. Naive T cells subjected to the same culture conditions were completely ineff...Continue Reading

Citations

Sep 13, 2011·Cellular & Molecular Immunology·Hui ZhaoWei He
Sep 3, 2003·Nature Reviews. Cancer·Mark E Dudley, Steven A Rosenberg
Jul 1, 1998·Journal of Neurosurgery·G E PlautzS Shu
Nov 8, 2003·Journal of Immunological Methods·Flemming MoellerLars B Nielsen
Apr 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B M SeeleyG E Plautz
May 29, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jorgen KjaergaardMichail Sitkovsky
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L PengP A Cohen
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L PengP A Cohen
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M H RyanS I Abrams
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liaomin PengPeter A Cohen
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KjaergaardS Shu
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G E PlautzS Shu
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingyong JiArthur A Hurwitz
Feb 6, 2021·Cancers·María Florencia MercoglianoRoxana Schillaci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.