PMID: 11315352Apr 24, 2001Paper

Treatment of systemic lupus erythematosus with bromocriptine

Lupus
S E Walker

Abstract

Prolactin, a lactogenic hormone, is a cytokine and an important link between the immune and endocrine systems. Prolactin stimulated disease in autoimmune NZB/NZW mice. Treatment of the mice with the prolactin-lowering dopamine agonist, bromocriptine, suppressed anti-DNA and prolonged life spans. These findings have been applied to humans with systemic lupus erythematosus (SLE). An open-label study, a double blind study, and a study comparing bromocriptine to hydroxychloroquine provided evidence that bromocriptine therapy reduced flares and suppressed disease activity in SLE.

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Citations

Feb 12, 2004·Autoimmunity Reviews·Fanny Monneaux, Sylviane Muller
Dec 1, 2005·Reumatología clinica·L J Jara-QuezadaM A Saavedra-Salinas
Apr 19, 2002·Paediatric Drugs·Luis CarreñoIndalecio Monteagudo
Mar 13, 2014·Journal of Neuroimmunology·Jorge CorrealeMaría Célica Ysrraelit
Jun 6, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Robert G Lahita
Jan 11, 2005·Rheumatic Diseases Clinics of North America·Martine Szyper-KravitzYehuda Shoenfeld
Aug 29, 2013·BioMed Research International·Oliva Mejía-RodríguezRamón Paniagua
Apr 9, 2014·Frontiers in Immunology·Rodrigo PachecoMoncef Zouali
May 10, 2006·Advances in Immunology·Betty DiamondBruce T Volpe
Aug 30, 2005·Annals of the New York Academy of Sciences·Alon Y Hershko, Yaakov Naparstek
Jul 22, 2018·F1000Research·Savino SciasciaMaria Laura Bertolaccini
Apr 9, 2005·Endocrine Reviews·Vincent GoffinPaul A Kelly
Jan 13, 2012·Annals of the New York Academy of Sciences·Mindy S Lo, George C Tsokos
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Renata S AuriemmaAnnamaria Colao

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