PMID: 9186538Apr 1, 1997Paper

Treatment of the anemia of aplastic anemia patients with recombinant human erythropoietin in combination with granulocyte colony-stimulating factor: a multicenter randomized controlled study. Multicenter Study Group

European Journal of Haematology
M BesshoY Kohgo

Abstract

A multicenter randomized controlled study was undertaken in order to determine whether epoetin beta (EPO) ameliorates the anemia in aplastic anemia (AA) patients treated with granulocyte colony-stimulating factor (G-CSF). Enrolled patients were randomized into 3 groups: group C receiving G-CSF alone as the control; group L receiving G-CSF and 200 IU/kg of EPO; group H receiving G-CSF and 400 IU/kg of EPO. Throughout the study, the dose and the administration interval of G-CSF were adjusted to maintain neutrophil counts between 1000 and 5000 microliters EPO was administered subcutaneously for 12 wk as the first step in treatment and when favorable effects were observed over this period, treatment was continued for another 12 wk as the second step in treatment. Significant erythroid responses were defined as increases in untransfused hemoglobin values > 1.0 g/dl or > 50% decreases in RBC transfusion requirements over the treatment period. Of 131 patients enrolled, 88 patients allocated to groups L and H were evaluated for toxicity to EPO and 110 were evaluated for erythroid responses. Four of the 31 patients (12.9%) in group C, 6 of the 41 patients (14.6%) of group L, and 14 of the 38 patients (36.8%) of group H showed erythroid ...Continue Reading

References

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Citations

Feb 12, 2005·Pediatric Blood & Cancer·Peter KurreH Joachim Deeg
Aug 4, 2005·Annals of Hematology·Michael Heuser, Arnold Ganser
Jul 28, 2005·Annals of Hematology·Michael Heuser, Arnold Ganser
May 4, 2018·Stem Cell Research & Therapy·Tzu-Lin ChenDer-Shan Sun
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Thomy ToniaJulia Bohlius
Aug 10, 2000·British Journal of Haematology·S E Ball
Nov 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R KurzrockM Talpaz
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Julia BohliusAndreas Engert
Nov 6, 2002·International Journal of Hematology·Yutaka KohgoJunji Kato
Apr 16, 2021·British Journal of Haematology·Phillip Scheinberg
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yves Beguin

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