Treatment of Toxic Multinodular Goiter: Comparison of Radioiodine and Long-Term Methimazole Treatment

Thyroid : Official Journal of the American Thyroid Association
F AziziAtieh Amouzegar

Abstract

Background: This study aimed to compare the effectiveness and safety of long-term methimazole (MMI) and radioiodine (RAI) in the treatment of toxic multinodular goiter (TMNG). Methods: In this randomized, parallel-group trial, 130 consecutive and untreated patients with TMNG, aged <60 years, were enrolled and randomized to either long-term MMI or RAI treatment. Both groups of patients were followed for 60-100 months, with median durations of 72 and 84 months in the MMI and RAI groups, respectively. Results: In the MMI and RAI groups, 12 and 11 patients, respectively, were excluded because of side effects, choosing other modes of treatment and not returning for follow-up; 53 and 54 patients, respectively, completed the study for 60-100 months. In the MMI group, two patients (3.8%) experienced subclinical hypothyroidism, and 51 (96.2%) remained euthyroid until the end of study. The dosage of MMI to maintain euthyroidism was 6.3 ± 2.0, 4.5 ± 0.9, and 4.1 ± 1.0 mg daily during the first, third, and fifth years of continuous MMI treatment. One patient had elevated liver enzymes, and three developed skin reactions during the first three months, but no adverse effects from MMI occurred from 4 to 100 months of therapy. In the RAI ...Continue Reading

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Citations

Apr 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Fereidoun Azizi
Aug 20, 2020·Thyroid : Official Journal of the American Thyroid Association·Fereidoun AziziAtieh Amouzegar
Jun 24, 2020·Wiener medizinische Wochenschrift·Christina Tugendsam, Amir Kurtaran
Feb 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Karen Tsai, Angela M Leung
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Fei ShenBo Xu

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