PMID: 11913495Mar 27, 2002Paper

Treatment of toxoplasmosis in pregnancy: concentrations of spiramycin and neospiramycin in maternal serum and amniotic fluid

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
R GratzlT Thalhammer

Abstract

Toxoplasma infection during pregnancy is widely treated with oral spiramycin to reduce the risk of congenital toxoplasmosis in the infant. Failures of therapy have been observed, however. In this study, a sensitive high-performance liquid chromatography technique was used to measure concentrations of spiramycin and neospiramycin, one of the major metabolites of spiramycin, in maternal serum and amniotic fluid. Samples were obtained from 18 women who underwent amniocentesis for polymerase chain reaction (PCR) diagnosis of fetal infection 5-109 days following the prescription of spiramycin therapy (3 g/day). Concentrations of spiramycin and neospiramycin in both serum and amniotic fluid were highly variable, ranging from nondetectable values to 1 microg/ml. None of the concentrations measured were within the range reported to inhibit growth of the parasite in vitro. Consistent with previous reports, part of the observed variability in maternal and fetal drug concentrations could be explained by individual differences in several pharmacokinetic parameters: intestinal absorption, tissue distribution, cellular uptake, metabolism, transfer across the placenta, drug accumulation in fetal tissue, and maternal and fetal drug elimination...Continue Reading

Citations

Jul 19, 2002·Prenatal Diagnosis
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Aug 28, 2007·The Pediatric Infectious Disease Journal·Hélène Fricker-HidalgoHervé Pelloux
Apr 12, 2012·Clinical Microbiology Reviews·Florence Robert-Gangneux, Marie-Laure Dardé
Nov 13, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·F A Habib
Nov 15, 2011·Trends in Parasitology·Florence Robert-GangneuxHervé Pelloux
Jun 10, 2008·Anatomia, histologia, embryologia·A K KarabulutZ Fazliogullari
Nov 17, 2011·Acta Tropica·Yves CarlierFrançois Peyron
Sep 11, 2014·Archives of Gynecology and Obstetrics·Stephanie M DavisJeffrey L Jones
Sep 12, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Reich-SchupkeM Stücker
Mar 16, 2017·Current Obesity Reports·Jameson D Voss, Nikhil V Dhurandhar

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