PMID: 10473232Sep 3, 1999Paper

Treatment of typhoid fever with azithromycin versus chloramphenicol in a randomized multicentre trial in India

The Journal of Antimicrobial Chemotherapy
T ButlerR B Johnson

Abstract

To compare the clinical and bacteriological efficacies of azithromycin and chloramphenicol for treatment of typhoid fever, 77 bacteriologically evaluable adults, with blood cultures positive for Salmonella typhi or Salmonella paratyphi A susceptible to their assigned drugs, were entered into a randomized open trial at four hospitals in India. Forty-two patients were randomized to receive azithromycin 500 mg p.o. od for 7 days and 35 to receive chloramphenicol 2-3 g p.o. od in four divided doses for 14 days. Thirty-seven patients (88%) in the azithromycin group responded with clinical cure or improvement within 8 days and 30 patients (86%) in the chloramphenicol group responded with cure or improvement. By day 14 after the start of treatment, all patients treated with azithromycin and all except two of the patients treated with chloramphenicol (94%) were cured or improved. Blood cultures repeated on day 8 after start of therapy showed eradication of organisms in 100% of patients in the azithromycin group and 94% of patients in the chloramphenicol group. By day 14 the eradication rate in the chloramphenicol group had increased to 97%. Stool cultures on days 21 and 35 after start of treatment showed no prolonged faecal carriage of...Continue Reading

References

Nov 1, 1992·The Journal of Antimicrobial Chemotherapy·A K UwaydahI Matar
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·S H NaqviB J Farooqui
Sep 12, 1991·The American Journal of Medicine·H C Neu
Nov 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·A K UwaydahJ C Davidson
Feb 10, 1990·Lancet·A C AnandS K Chatterjee
Jan 1, 1990·The Journal of Antimicrobial Chemotherapy·G FouldsR B Johnson
Sep 1, 1990·Reviews of Infectious Diseases·M O AsperillaL K Scott
May 1, 1989·The Journal of Antimicrobial Chemotherapy·F WangT Y Tai
Oct 1, 1988·The Journal of Infectious Diseases·A IslamA L Smith
Jan 1, 1995·The Journal of Antimicrobial Chemotherapy·A PascualE J Perea
Nov 1, 1994·The Pediatric Infectious Disease Journal·Z A BhuttaA M Molla
Feb 1, 1995·The American Journal of Tropical Medicine and Hygiene·G AcharyaU N Pathak
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·M D SmithN J White
Dec 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M R WallaceK C Hyams
Jul 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S MouradJ R Murphy
Feb 1, 1993·Scandinavian Journal of Gastroenterology·P DuttaA Mukherjee
May 1, 1993·Antimicrobial Agents and Chemotherapy·P DuttaM Lahiri
May 1, 1996·Journal of Medical Microbiology·S H MirzaC A Hart
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D TribbleT Butler
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·A WildfeuerT Zimmermann
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B RoweE J Threlfall
Aug 1, 1997·Epidemiology and Infection·R KhakhriaC Poppe

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Citations

Jul 17, 2003·Current Gastroenterology Reports·Nancy F Crum
May 13, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christopher M Parry
Nov 29, 2002·The New England Journal of Medicine·Christopher M ParryJeremy J Farrar
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A CrumpFrederick J Angulo
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert W FrenckCharles Knirsch
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara E MurrayWilliam B Greenough
Jun 22, 2011·Antimicrobial Agents and Chemotherapy·Maria Sjölund-KarlssonJean M Whichard
Dec 29, 2012·PLoS Neglected Tropical Diseases·Erika R VliegheJan A Jacobs
Apr 29, 2003·Paediatric Drugs·Nopaorn Phavichitr, Anthony Catto-Smith
Oct 12, 2010·Journal of Global Infectious Diseases·Malini Rajinder Capoor, Deepthi Nair
Mar 25, 2014·Emerging Infectious Diseases·Robert-Jan HassingPerry J J van Genderen
Apr 10, 2014·Indian Journal of Medical Microbiology·L SinghalP Ray
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sayomporn SirinavinSomchit Junumporn
Apr 10, 2014·Indian Journal of Medical Microbiology·V BalajiA Kapil
Dec 8, 2009·The Journal of Infection·Tristan W ClarkIain Stephenson
Aug 30, 2005·Lancet·M K BhanShinjini Bhatnagar
Feb 12, 2009·Journal of Medical Microbiology·Malini R CapoorParukutty Pillai
Aug 28, 2015·Singapore Medical Journal·Yee Wei PhoonTze Hsien Koh
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J M Duran, G W Amsden
Apr 16, 2016·Indian Journal of Medical Microbiology·U RameshA Balasubramanian
May 26, 2015·Clinics in Laboratory Medicine·Romney M Humphries, Audrey N Schuetz
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P ImbertT Debord
Jun 23, 1999·Mayo Clinic Proceedings·S Alvarez-Elcoro, M J Enzler
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Emmanuel E Effa, Hasifa Bukirwa
Nov 20, 2018·PLoS Neglected Tropical Diseases·Mari Kajiwara SaitoShunmay Yeung
Sep 21, 2012·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Yasutaka MizunoTetsuya Matsumoto
Feb 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Agila Kumari PragasamAnkur Mutreja

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