PMID: 2109004Apr 1, 1990Paper

Treatment of ulcerative colitis with fish oil n--3-omega-fatty acid: an open trial

Journal of Clinical Gastroenterology
P SalomonH D Janowitz

Abstract

We evaluated the efficacy of fish oil n--3-omega-fatty acids, inhibitors of leukotriene synthesis, in the treatment of ulcerative colitis. An open trial of 10 patients with mild to moderate ulcerative colitis who had either failed (n = 9) or refused (n = 1) conventional therapy was performed. Patients received 15 MAX-EPA capsules containing a total of 2.7 g of eicosapentanoic acid in three divided doses daily for 8 weeks. The activity of ulcerative colitis and response to therapy was based upon daily stool diaries, sigmoidoscopy, and symptomatic response. All patients tolerated the fish oil and showed no alteration in routine blood studies. Seven patients had moderate to marked improvement; steroid dose could be reduced in four of the five patients on prednisone. Three patients had little or no improvement. No patient worsened. These results of our open study appear to justify a double-blind trial of this dietary supplement in ambulatory patients with ulcerative colitis.

Citations

Oct 1, 1996·Digestive Diseases and Sciences·K LoeschkeR Lorenz
Jul 27, 2001·Current Gastroenterology Reports·M A Gassull
Jul 1, 1995·Gastroenterology·C E Eberhart, R N Dubois
Mar 20, 1998·Advances in Internal Medicine·S J Bickston, F Cominelli
Feb 6, 2002·Pediatric Clinics of North America·Timothy Sentongo, Maria R Mascarenhas
Feb 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J M CampbellK A Garleb
Nov 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A Gil
Jun 18, 1999·Gastroenterology Clinics of North America·B E Sands
Jun 18, 1999·Gastroenterology Clinics of North America·P D HanG R Lichtenstein
Apr 12, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas L SeidnerStephen J Demichele
May 25, 2012·The British Journal of Nutrition·Eduard CabréMiquel A Gassull
Jan 1, 1995·Nutrition Research Reviews·K R GardinerB J Rowlands
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Oct 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Angel Gil
Oct 1, 1995·Inflammatory Bowel Diseases·A Bitton, M A Peppercorn
Jan 1, 1993·Journal of Gastroenterology and Hepatology·W Selby
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Ryoichi SohmaHajime Kuwayama
Oct 15, 2013·Nutrition Reviews·Michael R FlockPenny M Kris-Etherton
Mar 20, 2002·The British Journal of Nutrition·F G CamposP Fürst
Mar 1, 1997·Baillière's Clinical Gastroenterology·A BurkeJ L Rombeau
Jan 4, 2017·Prostaglandins & Other Lipid Mediators·Weicang WangGuodong Zhang
Apr 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·S N Meydani, C A Dinarello
Oct 19, 2007·The Cochrane Database of Systematic Reviews·M De LeyP Stokkers
Sep 9, 2010·Molecular Nutrition & Food Research·Jae Young ChoHyang Sook Chun
Jun 13, 1998·The American Journal of Gastroenterology·Y Z AlmallahO Eremin
May 28, 2008·Molecular Nutrition & Food Research·Philip C Calder
Jul 1, 2005·Expert Review of Clinical Immunology·Jennifer Durber, Anthony Otley
Oct 20, 2005·Clinical and Experimental Immunology·S C MillsS C Knight
Apr 18, 2013·Diabetes/metabolism Research and Reviews·Michael R FlockPenny M Kris-Etherton
Mar 26, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Caroline MorinSamuel Fortin
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·S EndresK Loeschke
Dec 4, 2009·International Reviews of Immunology·Philip C Calder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.