Abstract
Sixteen patients with unresectable recurrent head and neck carcinomas were treated with 13-cis-retinoic acid and interferon-alpha. All patients had presented with recurrences after having been treated primarily with surgery and radiotherapy, while two of them had also received induction chemotherapy. The site of relapse was strictly locoregional in all cases (only at the primary site in three cases, at the cervical lymph nodes only in four cases and both at the primary site and the neck in the remaining nine cases. Two patients were female, and 14 male, with an age range of 47-72 years (median 61 years). Interferon-alpha was administered subcutaneously at a dose of 3 x 10(6) IU every second day. The dose of retinoids was 40 mg per os every day. The duration of treatment was two to 14 months (median seven months). There were two cases of partial response (tumour regression > 50 per cent), eight cases of stable disease lasting for three to seven months (median four months) and six cases presented with progressive disease. All patients died after a survival of three to 17 months (median 9.5 months). Toxicity was generally minimal. We believe that the results are not encouraging, but also not disappointing. The fact that toxicity w...Continue Reading
References
Jan 1, 1992·Archives of Otolaryngology--head & Neck Surgery·G L ClaymanS P Schantz
Nov 1, 1992·The Annals of Otology, Rhinology, and Laryngology·G L ClaymanS P Schantz
May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A SmithM A Friedman
Feb 19, 1992·Journal of the National Cancer Institute·E Dmitrovsky, G J Bosl
Feb 19, 1992·Journal of the National Cancer Institute·S M LippmanW K Hong
Feb 19, 1992·Journal of the National Cancer Institute·S M LippmanI H Krakoff
Feb 1, 1991·Journal of the American Academy of Dermatology·R M KnoblerM Micksche
Nov 1, 1990·Archives of Otolaryngology--head & Neck Surgery·W J RichtsmeierE H Chang
Nov 1, 1990·Archives of Otolaryngology--head & Neck Surgery·S P SchantzH Savage
Nov 2, 1988·Journal of the National Cancer Institute·S A RosenbergP J Spiess
Jul 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I F Tannock, G Browman
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G Taylor
Apr 1, 1994·Journal of Chemotherapy·G Fountzilas
Jan 1, 1993·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·W J IssingE R Kastenbauer
Feb 1, 1993·Investigational New Drugs·N VoravudW K Hong
Citations
May 20, 1998·Dermatologic Clinics·R Stadler
Sep 25, 2001·Journal of the American Academy of Dermatology·M LebwohlP McClelland
Apr 9, 2002·Acta Oto-laryngologica·Alfio FerlitoAshok R Shaha
Apr 6, 2005·International Journal of Dermatology·Sadiye KusHaydar Sur