Treatment of uterine papillary serous carcinoma with platinum-based chemotherapy and paclitaxel

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
A P VaidyaLinda R Duska

Abstract

Uterine papillary serous carcinoma (UPSC) is more aggressive than endometrioid endometrial cancer, as it often presents with advanced disease and follows a pattern of spread that resembles the serous carcinoma of the ovary. There exists little data on evaluating the combination of carboplatin and paclitaxel in UPSC. Institutional Review Board permission was obtained for a retrospective review. Tumor registry search was used to identify all patients with UPSC from 1990 to 2003. Charts were retrospectively evaluated from patients who had received at least three cycles of carboplatin and paclitaxel as first-line chemotherapy. Only patients with histologically confirmed UPSC who were treated first line with carboplatin/paclitaxel chemotherapy were included. Nineteen patients with UPSC were identified, who were treated with carboplatin and paclitaxel in the first-line adjuvant setting after initial surgical cytoreduction. All patients received at least three cycles, with 12 of the 19 patients receiving six cycles. Five patients were treated with consolidation radiotherapy following first-line chemotherapy. Mean age was 69 years (range 55-88). The majority of patients had stage III disease (n= 11). Mean follow-up for the group was 29...Continue Reading

References

Feb 1, 1991·Obstetrical & Gynecological Survey·C J DuntonE Hernandez
Jul 1, 1987·Gynecologic Oncology·G P SuttonC E Ehrlich
Mar 1, 1982·The American Journal of Surgical Pathology·M HendricksonR Kempson
Sep 1, 1996·Clinical Obstetrics and Gynecology·J L Nicklin, L J Copeland
Jan 12, 2001·Obstetrics and Gynecology·P A GehrigL Van Le
Jun 28, 2001·Gynecologic Oncology·L RamondettaD M Gershenson
Oct 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J HoskinsN Lee
Feb 22, 2003·Current Treatment Options in Oncology·Felice D Lackman, Peter S Craighead
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B Sorbe

❮ Previous
Next ❯

Citations

Oct 22, 2008·Current Oncology Reports·R Wendel Naumann
Jun 15, 2014·Gynecologic Oncology·William M BurkeUNKNOWN Society of Gynecologic Oncology Clinical Practice Committee
Feb 12, 2011·Seminars in Diagnostic Pathology·Diana Lim, Esther Oliva
May 30, 2009·Gynecologic Oncology·Jacqueline MorganBarbara M Buttin
Sep 9, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Emma C BatchelorJoseph M Jenrette
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Krystine LupeMark S Carey
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Jul 14, 2009·Gynecologic Oncology·David M BorutaAlexander B Olawaiye
Nov 28, 2007·Annual Review of Pathology·Antonio Di Cristofano, Lora Hedrick Ellenson
Apr 29, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jose Alejandro Rauh-HainMarcela G del Carmen
Nov 21, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Carin BlackOrla McNally
Nov 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ivy Wilkinson-RyanAndrea R Hagemann
Jan 17, 2008·Current Opinion in Obstetrics & Gynecology·Chad A HamiltonJohn K Chan
Nov 10, 2012·Current Opinion in Obstetrics & Gynecology·Dana M Roque, Alessandro D Santin
Dec 3, 2016·Multivariate Behavioral Research·Daniel McNeish, Denis Dumas
Jul 24, 2021·Abdominal Radiology·Cibele LunaFrancesco Alessandrino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.