Treatment of Uveitis by In Situ Administration of Ex Vivo-Activated Polyclonal Regulatory T Cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sylvie GrégoireBenoît L Salomon

Abstract

CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cell therapy is a promising approach for the treatment of autoimmune diseases. To be effective, Treg cells should be in an activated state in the target tissue. This can be achieved by systemic administration of Ag-specific Treg cells, which are difficult to produce in conditions that can be translated to the clinic. In this paper, we propose an alternative approach consisting of in situ injection of preactivated polyclonal Treg cells that would exert bystander suppression in the target tissue. We show that polyclonal Treg cells suppressed uveitis in mice as efficiently as Ag-specific Treg cells but only when preactivated and administered in the vitreous. Uveitis control was correlated with an increase of IL-10 and a decrease of reactive oxygen species produced by immune cell infiltrates in the eye. Thus, our results reveal a new mechanism of Treg cell-mediated suppression and a new Treg cell therapy approach.

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Citations

Apr 28, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arnaud FoussatBahram Bodaghi
Jun 12, 2018·Journal of Immunology Research·Hiroshi KeinoSunao Sugita
Oct 26, 2018·Frontiers in Immunology·Igal Gery, Rachel R Caspi
Sep 25, 2018·Transplantation·Chunyi ShaoReza Dana
Oct 9, 2019·Seminars in Immunopathology·Gerhild Wildner, Maria Diedrichs-Möhring
Jul 28, 2020·Progress in Retinal and Eye Research·Arsia JamaliPedram Hamrah

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