PMID: 7540526Mar 1, 1995Paper

Treatment of vasculitic leg ulcers in connective tissue disease with iloprost

Clinical Rheumatology
D J VealeJ J Belch

Abstract

Leg ulcers are a recognised manifestation of cutaneous vasculitis in connective tissue diseases (CTDs) including rheumatoid arthritis (RA). Iloprost a stable prostacyclin analogue has been successfully used to treat Raynaud's phenomenon and digital ulcers associated with CTD's. Our aim was to assess iloprost in the treatment of vasculitic leg ulcers in CTD. In this paper we describe eight cases of vasculitic leg ulceration in association with RA and CTD, treated with intravenous iloprost. The iloprost was administered for 6-8 hours daily and continued for 21-28 days. Immunosuppressive therapy was required in three patients with severe necrotising vasculitis (RAnv). Complete ulcer healing was achieved in four patients within 6 weeks of commencing therapy while rapid improvement occurred in the other four patients. This suggests that iloprost may be useful as an adjunct to therapy for vasculitic leg ulcers. A double-blind placebo controlled study of iloprost therapy for RA leg ulcers is under way.

References

Jun 1, 1988·British Journal of Rheumatology·D A YardumianS J Machin
Apr 1, 1965·Scottish Medical Journal·M WILKINSON, J KIRK

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Citations

Jan 6, 2001·The Pediatric Infectious Disease Journal·M R RobinsonT J Walsh
Nov 5, 2013·Annals of Vascular Surgery·Rhiannon L HarriesDean T Williams
Nov 9, 2010·Dermatologic Therapy·Gionata BuggianiTorello Lotti
Dec 15, 2015·The International Journal of Lower Extremity Wounds·Massimo Papi, Claudia Papi
Feb 23, 2018·Clinical Rheumatology·S Bellando-RandoneM Matucci-Cerinic
Sep 24, 2005·Journal of Integrative Neuroscience·Roman R Poznanski
Dec 22, 1998·Seminars in Cutaneous Medicine and Surgery·M Flour, H Degreef

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