Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline

Transactions of the Royal Society of Tropical Medicine and Hygiene
Suman RijalS Koirala

Abstract

Sodium stibogluconate (SSG) is the first-line therapy for visceral leishmaniasis (VL) in south-eastern Nepal. Recent studies from the neighbouring state of Bihar, India, have shown a dramatic fall in cure rates with treatment failure occurring in up to 65% of VL patients treated with SSG. A prospective study was conducted at a tertiary-level hospital located in south-eastern Nepal from July 1999 to January 2001. Parasitologically proven kala-azar patients with no previous history of treatment for VL were treated with SSG 20 mg/kg/d for 30 d which was extended to 40 d in those with persistent positive parasitology. Of the 110 patients who completed SSG therapy and were assessed at 1 and 6 months, definite cure was achieved in 99 patients (90%) and SSG failure occurred in 11 patients (10%). Except for the presence of hepatomegaly and a lower platelet count there was no clinical or laboratory baseline characteristic associated with treatment failure. A significantly lower cure rate (76%, P = 0.03) was observed in patients from the district of Saptari, which borders the antimony-resistant VL areas of Bihar. The efficacy of SSG as a first-line treatment for VL in south-eastern Nepal was still satisfactory, except for the patients li...Continue Reading

References

Mar 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·C N ChungeL Donno
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A D BrycesonG Anabwani
Jan 29, 1994·BMJ : British Medical Journal·S SundarV P Singh
Sep 1, 1996·Clinics in Dermatology·P Desjeux
Dec 10, 1999·The New England Journal of Medicine·T K JhaJ Berman
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S SundarH W Murray
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S SundarH W Murray
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M BoelaertP Van der Stuyft
Jun 5, 2001·The American Journal of Tropical Medicine and Hygiene·C BernM B Bista
Aug 9, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Desjeux
Nov 13, 2001·Tropical Medicine & International Health : TM & IH·S Sundar
Nov 13, 2001·Tropical Medicine & International Health : TM & IH·S L Croft
Nov 13, 2001·Tropical Medicine & International Health : TM & IH·A Bryceson
Feb 14, 2002·Tropical Medicine & International Health : TM & IH·Andrew S FurberMarianne M Lubben

❮ Previous
Next ❯

Citations

Sep 4, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·S RijalF Chappuis
Sep 28, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Workagegnehu HailuAsrat Hailu
Aug 31, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caryn BernJorge Alvar
Feb 22, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suman RijalJean-Claude Dujardin
Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Saskia DecuypereJean-Claude Dujardin
Apr 11, 2008·Clinical Microbiology Reviews·Jorge AlvarJavier Moreno
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Sep 15, 2010·PLoS Neglected Tropical Diseases·Filip MeheusMarleen Boelaert
Mar 8, 2013·PLoS Neglected Tropical Diseases·Surendra UranwMarleen Boelaert
May 3, 2014·PLoS Neglected Tropical Diseases·Caspar J HodiamontTom van Gool
Sep 3, 2010·PloS One·Manu VanaerschotSaskia Decuypere
Jul 8, 2010·Journal of Global Infectious Diseases·E M Moore, D N Lockwood
Jul 8, 2010·Journal of Global Infectious Diseases·Jaya Chakravarty, Shyam Sundar
Nov 6, 2013·The American Journal of Tropical Medicine and Hygiene·Filip MeheusAhmed M Musa
Jan 8, 2011·The American Journal of Tropical Medicine and Hygiene·Basu Dev PandeyKenji Hirayama
Nov 26, 2010·Annals of Tropical Medicine and Parasitology·M BoelaertP Lutumba
Jan 12, 2008·Annals of Tropical Medicine and Parasitology·Y MuellerF Chappuis
Dec 6, 2008·Parasitology Research·Maria Irma Seixas DuarteFelipe Francisco Tuon
Sep 26, 2014·Nanomedicine·C D Shaw, K C Carter
Oct 28, 2014·Expert Opinion on Pharmacotherapy·Shyam Sundar, Jaya Chakravarty
Nov 21, 2014·Expert Opinion on Investigational Drugs·Shyam Sundar, Jaya Chakravarty
Jan 16, 2016·International Journal of Pharmaceutics·M A CollierK M Ainslie
Jan 20, 2016·Drug Discovery Today·Tina S Skinner-AdamsKatherine T Andrews
Oct 17, 2009·Social Science & Medicine·Wietse A TolJoop T V M de Jong
Nov 18, 2011·Molecular Biology International·Arun Kumar HaldarSyamal Roy
Feb 21, 2009·Tropical Medicine & International Health : TM & IH·Narayan Raj BhattaraiJean-Claude Dujardin
Oct 31, 2009·Tropical Medicine & International Health : TM & IH·Rogéria C Zauli-NascimentoSilvia R B Uliana
Dec 4, 2012·Tropical Medicine & International Health : TM & IH·Surendra UranwMarleen Boelaert
Dec 3, 2015·Tropical Parasitology·Shyam Sundar
Nov 1, 2005·Lancet·Henry W MurrayNancy G Saravia
Sep 7, 2012·Critical Reviews in Microbiology·Manu VanaerschotJean-Claude Dujardin
Oct 24, 2006·Tropical Medicine & International Health : TM & IH·Filip MeheusShyam Sundar
May 6, 2015·International Journal for Parasitology. Drugs and Drug Resistance·Philippe LeprohonMarc Ouellette
Jul 27, 2014·Free Radical Biology & Medicine·Krishn Pratap SinghVahab Ali
Dec 2, 2005·Expert Opinion on Pharmacotherapy·Shyam Sundar, Madhukar Rai
Dec 22, 2012·Expert Opinion on Pharmacotherapy·Shyam Sundar, Jaya Chakravarty
Jul 25, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Katherine T AndrewsTina S Skinner-Adams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Shyam SundarH W Murray
Tropical Medicine & International Health : TM & IH
Shyam Sundar
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Shyam SundarH W Murray
Transactions of the Royal Society of Tropical Medicine and Hygiene
Suman RijalFrançois Chappuis
© 2022 Meta ULC. All rights reserved