Treatment of Vogt-Koyanagi- Harada's disease during pregnancy

Japanese Journal of Ophthalmology
N MiyataS Ohno

Abstract

Caution should be exercised in treating patients with autoimmune diseases during pregnancy. We successfully treated three cases of Vogt-Koyanagi-Harada's disease (VKH disease) during pregnancy. In the second trimester (14-27 weeks) of 1 patient, inflammation was mild and could be treated by topical corticosteroid. There is the possibility that her immune response had been modified by pregnancy. Systemic corticosteroid in a high dose was administered to the two cases in the second and third trimesters of pregnancy (28-41 weeks). The severity of inflammation in these 2 patients was similar to that in nonpregnant women. Inflammation subsided immediately without recurrence in all cases. No abnormality was found during the deliveries or in the babies. Treatment for VKH disease during pregnancy should be chosen according to the severity of inflammation, the stage of pregnancy, and the maternal and fetal conditions.

Citations

Apr 7, 2006·Ocular Immunology and Inflammation·Leila I KumpWilliam G Christen
Mar 25, 2016·Orphanet Journal of Rare Diseases·Marcelo Mendes LavezzoJoyce Hisae Yamamoto
Apr 1, 2014·Journal of Ophthalmology·Nathalie P Y Chiam, Lyndell L P Lim

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