Treatment of W. bancrofti (Wb) in HIV/Wb coinfections in South India

PLoS Neglected Tropical Diseases
Kawsar R TalaatThomas B Nutman

Abstract

The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coincident infections. To assess the influence of pre-existing Wuchereria bancrofti infection on HIV progression, we performed a case-controlled treatment study of HIV positive individuals with (FIL+) or without (FIL-) W. bancrofti infection. Twenty-eight HIV+/FIL+ and 51 matched HIV+/FIL- subjects were treated with a single dose of diethylcarbamazine and albendazole (DEC/Alb) and followed for a year at regular intervals. Sixteen of the HIV+/FIL+ subjects (54%) and 28 of the HIV+/FIL- controls (57%) were on antiretroviral therapy (ART) during the study. Following treatment, no differences were noted in clinical outcomes between the 2 groups. There also was no significant difference between the groups in the HIV viral load at 12 months as a percentage of baseline viral load (HIV+/FIL+ group had on average 0.97 times the response of the HIV+/FIL- group, 95% CI 0.88, 1.07) between the groups. Furthermore, there were no significant differences found in either the change in viral load at 1, 3, or 6 months or in the change in CD4 count at 3, 6, or 12 months between the 2 groups. We were unable to find a significant effect of W. ban...Continue Reading

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Citations

Dec 1, 2017·Current Tropical Medicine Reports·Emily E Evans, Mark J Siedner

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
pregnancy test
ELISA
hysterectomy
MDA

Software Mentioned

R

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