PMID: 9178732Jun 1, 1997Paper

Treatment of Wilson's disease with zinc: XIV. Studies of the effect of zinc on lymphocyte function

The Journal of Laboratory and Clinical Medicine
G J BrewerJ Kaplan

Abstract

Although administration of zinc to human subjects has been reported to interfere with lymphocyte function, this single report has never been confirmed or refuted. We have developed zinc as a lifelong therapy for patients with Wilson's disease. Interference with lymphocyte function occurring as a side effect of zinc therapy could produce serious problems in our patients. We evaluated lymphocyte mitogenic response and natural killer cell activity in patients with Wilson's disease treated for 5 years or longer with zinc, in comparison with normal controls, and found no differences. In a second study, we evaluated these same parameters in patients with Wilson's disease before and after 1 year of zinc therapy, and again found no significant differences. We have seen no indications of immune suppression or increased susceptibility to infections in our patients, who have now been treated with zinc for up to 15 years. We conclude that any side effects from compromised lymphocyte function caused by administration of zinc are not of concern to patients with Wilson's disease.

Associated Clinical Trials

References

Jun 1, 1990·Journal of the American College of Nutrition·J D BogdenB K Holland
Feb 1, 1987·Journal of the Neurological Sciences·T U HoogenraadC J Van den Hamer
Oct 1, 1982·Journal of Clinical Immunology·J KaplanJ Smith
Sep 21, 1984·JAMA : the Journal of the American Medical Association·R K Chandra
Apr 1, 1993·The American Journal of the Medical Sciences·G J BrewerY Wang

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Citations

Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·G J Brewer
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·G J Brewer
Jul 26, 2013·World Journal of Gastroenterology : WJG·Anna WiernickaPiotr Socha
Dec 28, 2006·Journal of the American Academy of Dermatology·Emanual MaverakisNasim Fazel
Sep 11, 1999·The Journal of Laboratory and Clinical Medicine·G J Brewer
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G J BrewerK J Kluin
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN American Association for Study of Liver Diseases (AASLD)
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Jennifer R Evans, John G Lawrenson

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