Treatment of X-linked hereditary nephritis in Samoyed dogs with angiotensin converting enzyme (ACE) inhibitor

Journal of Comparative Pathology
K M GrodeckiRobert M Jacobs

Abstract

X-linked hereditary nephritis (HN) in Samoyed dogs is a model for human HN (Alport's syndrome). Angiotensin converting enzyme (ACE) inhibitors have been shown to slow the progression of renal disease in animal models and human patients. To determine the effect of ACE inhibitor treatment on X-linked HN in Samoyed dogs, a group of affected and a group of normal males were each randomly divided into two subgroups, which were either treated with an ACE inhibitor or left untreated. ACE inhibitor treatment caused significant increases (P < 0.05) in plasma renin activity in normal and affected dogs, confirming its effectiveness, but did not lower systemic blood pressure. Three of four affected treated dogs had improved weight gains and, overall, treated dogs survived 1.36 times longer than affected untreated dogs (P < 0.05). ACE inhibitor treatment of affected dogs significantly delayed (P < 0.05) the onset of an increase in serum creatinine concentration, tended to delay the decline of glomerular filtration rate and effective renal plasma flow (ERPF), significantly improved (P < 0.05) the ERPF at 110-154 days of age, and significantly slowed (P < 0.01) the rate of increase of proteinuria. Affected treated dogs showed a significant (P...Continue Reading

References

Aug 1, 1992·Kidney International·H R Brunner
Jul 1, 1992·Cleveland Clinic Journal of Medicine·D ChangW E Smith
Jan 1, 1987·Acta Anatomica·M ArighiF D Horney
Mar 1, 1987·Kidney International·T W MeyerB M Brenner
Jan 1, 1985·Kidney International·J P Grünfeld
Jan 1, 1974·Seminars in Nuclear Medicine·M L Cohen
Nov 1, 1981·European Journal of Biochemistry·R TimplK Kühn
Jul 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·G R Marchand
Feb 1, 1994·Kidney International·P M ter Wee, A J Donker
Jan 1, 1993·Kidney International·K TryggvasonT B Shows

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Citations

Apr 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clifford E Kashtan
Oct 7, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marina CharbitPatrick Niaudet
Oct 14, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hiroshi KaitoMasafumi Matsuo
Oct 4, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clifford E Kashtan
Apr 2, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dominic Cosgrove
Mar 31, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clifford E KashtanUNKNOWN Alport Syndrome Research Collaborative
Jun 25, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael PohlHeidrun Rhode
Jul 21, 2010·Nature Reviews. Nephrology·Chih-Kang Chiang, Reiko Inagi
Feb 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas J A WebbCéline Le Bailly De Tilleghem
Dec 5, 2003·Veterinary Clinical Pathology·J P BraunA D J Watson
Mar 29, 2008·Journal of Veterinary Internal Medicine·O CortadellasA Bayón
Feb 2, 2010·American Journal of Veterinary Research·Andrea ZatelliEric Zini
Jun 19, 2009·Kidney International·Oliver Gross, Clifford E Kashtan
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·David J Polzin
Mar 9, 2013·Journal of Veterinary Emergency and Critical Care·David J Polzin
Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Isavella SavvaConstantinos Deltas
Oct 2, 2014·Journal of Veterinary Internal Medicine·A C BugbeeS A Brown
Mar 8, 2013·Journal of Veterinary Emergency and Critical Care·George E Lees
Jan 1, 2014·Journal of Veterinary Internal Medicine·O CortadellasM J Fernández del Palacio
Oct 27, 2004·Journal of Veterinary Pharmacology and Therapeutics·H P Lefebvre, P L Toutain
Oct 26, 2005·The Journal of Small Animal Practice·G F Grauer
Apr 21, 2010·The Journal of Small Animal Practice·P RoudebushS D Forrester
Oct 30, 2014·Frontiers in Endocrinology·Rachel LennonMartin J Humphries
Mar 13, 2003·Kidney International·Mauro Abbate, Giuseppe Remuzzi
Jun 16, 2007·Nephron. Clinical Practice·Paul Scott Thorner
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Gregory F Grauer
Feb 27, 2019·Journal of Veterinary Internal Medicine·Marisa K AmesBertram Pitt
Nov 23, 2013·Journal of the American Society of Nephrology : JASN·Xiaobo LinJeffrey H Miner
Feb 11, 2005·Journal of the American Veterinary Medical Association·Frédéric JacobLaurie L Swanson
May 30, 2012·Nature Reviews. Nephrology·Judy Savige
Jan 23, 2013·Nature Reviews. Nephrology·Norman Sachs, Arnoud Sonnenberg
Nov 21, 2012·Nature Reviews. Nephrology·Jenny KruegelOliver Gross
Jul 17, 2014·Journal of the American Animal Hospital Association·Christina MamoneMark Acierno
Feb 18, 2020·Clinical Science·Holly Mabillard, John A Sayer
Jun 14, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roser Torra, Mónica Furlano
Nov 10, 2020·Journal of Veterinary Internal Medicine·Bianca N LourençoKate E Creevy
Sep 30, 2020·Research in Veterinary Science·Yuichi MiyagawaNaoyuki Takemura
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Dilys ChenPaul S Thorner
Jun 6, 2021·Research in Veterinary Science·H MiyakawaN Takemura
Apr 19, 2005·The Veterinary Clinics of North America. Small Animal Practice·Gregory F Grauer
Apr 30, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony ChangStephen L Seliger
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Meryl P Littman
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Harriet Syme

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