Treatment of young rams with an agonist of GnRH delays reproductive development

Hormones and Behavior
A J TilbrookI J Clarke

Abstract

The objective of this study was to determine if the continuous treatment of young rams with an agonist of gonadotropin-releasing hormone (GnRH) in the period immediately prior to puberty would delay the onset of adult sexual behavior and retard testicular development. In the first experiment the GnRH agonist was shown to be effective in suppressing the plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in adult wethers (neonatally castrated rams) when administered by either a biocompatible slow release implant (implant) or a mini osmotic pump (minipump) that released the agonist for 4 weeks. The minipumps were more effective than the implants in suppressing the secretion of LH and FSH. In a second experiment, administration of the GnRH agonist by implant or minipump to prepubertal rams for 16 weeks immediately prior to puberty inhibited the development of sexual behavior, reduced the plasma concentrations of testosterone, retarded testicular and epididymal development, and inhibited growth rates. The effects on sexual behavior were clearly reversible but testicular and epididymal weights were still reduced in treated rams 8 weeks after the end of treatment. These results indicate that the r...Continue Reading

Citations

Feb 20, 2004·Archives of Physiology and Biochemistry·G GenaroA A M Rosa e Silva
May 8, 2007·Hormones and Behavior·Anne Perkins, Charles E Roselli
Apr 18, 2006·Animal Reproduction Science·H Jiménez-SeverianoJ E Kinder
Oct 19, 2004·Physiology & Behavior·Charles E RoselliFredrick Stormshak
May 18, 2016·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Lisa MihslerAxel Wehrend

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