Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing

AIDS
Maria CasadellàRoger Paredes

Abstract

In a South African cohort of participants living with HIV developing virological failure on first-line tenofovir disoproxyl fumarate (TDF)-based regimens, at least 70% of participants demonstrated TDF resistance according to combined Sanger and MiSeq genotyping. Sanger sequencing missed the K65R mutation in 30% of samples. Unless HIV genotyping is available to closely monitor epidemiological HIV resistance to TDF, its efficacy as second-line therapy will be greatly compromised.

References

Oct 16, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Damian J McCollMichael D Miller
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tommy F Liu, Robert W Shafer
Jun 12, 2013·Antiviral Therapy·Christopher J HoffmannLynn Morris
Jul 12, 2014·The New England Journal of Medicine·Nicholas I PatonUNKNOWN EARNEST Trial Team

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Citations

Nov 8, 2016·Virus Research·Maria Casadellà, Roger Paredes
Oct 13, 2016·The Journal of Infectious Diseases·Ellen WhiteUNKNOWN UK HIV Drug Resistance Database and UK Collaborative HIV Cohort Study
Jan 28, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cissy KityoUNKNOWN Europe Africa Research Network for Evaluation of Second-line Therapy (EARNEST) Trial Team
Oct 3, 2017·The Journal of Infectious Diseases·Marc Noguera-JulianRoger Paredes
Dec 6, 2017·The Journal of Infectious Diseases·Natalia Stella-AscarizJonathan Z Li
May 12, 2018·Journal of Medical Virology·Florence NicotJacques Izopet
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dami CollierUNKNOWN French National Agency for AIDS and Viral Hepatitis Research (ANRS) 12249 Treatment as Prevention (TasP) Study Group
Oct 21, 2021·Microbiology Spectrum·Horeyah Sarkhouh, Wassim Chehadeh

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Methods Mentioned

BETA
genotyping

Software Mentioned

MiSeq

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