Treatment options and considerations for hypertensive patients to prevent dementia

Expert Opinion on Pharmacotherapy
Intza HernandorenaO Hanon

Abstract

Dementia is a worldwide health concern, which leads to loss of autonomy. To date no curative treatment is available so focus on modifiable risk factors is of particular interest. Hypertension, particularly midlife high blood pressure, has been associated with an increased risk for cognitive decline and dementia including vascular dementia (VAD) and Alzheimer disease (AD). In this context, antihypertensive treatments might have a preventive effect. The objective of this review was to examine the relationship between antihypertensive therapy and cognitive decline or dementia. Areas covered: A literature search was conducted using PUBMED and the COCHRANE LIBRARY for publications from 1990 onwards mentioning cognitive decline, AD, Vad, mixed dementia, vascular cognitive impairment, hypertension and antihypertensive therapy. Thirty-nine relevant publications including 20 longitudinal studies, 10 randomized-controlled trials and 9 meta-analyses were taken into account. Expert opinion: Most observational studies have suggested a potential preventive effect of antihypertensive therapies on cognitive decline and dementia, particularly calcium channel blockers and renin-angiotensin system blockers. Randomized clinical trials and meta-ana...Continue Reading

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Citations

Nov 20, 2018·Journal of Human Hypertension·Hui LiXingsheng Zhao
May 29, 2018·Clinical Science·Mariela M GironacciMauro G Silva
Jan 23, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Pramod Kumar KuchulakantiVcs Srinivasarao Bandaru
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Aug 5, 2021·Dementia & Neuropsychologia·Bruna Moretti LuchesiTatiana Carvalho Reis Martins

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