Treatment options for venous leg ulcers: effectiveness of vascular surgery, bioengineered tissue, and electrical stimulation

Advances in Skin & Wound Care
Gaurav ThakralLawrence A Lavery

Abstract

To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical trials comparing advanced treatment with standard of care using compression dressing were included. A total of 7 bioengineered tissue, 4 surgical treatment, and 4 electrical stimulation randomized clinical trials were identified. Compared with nonstandard treatments, electrical stimulation demonstrated improved wound healing, fewer adverse events, and shorter duration of healing. Healing rates at the end of the study were greater for surgical intervention, followed by similar outcomes for electrical stimulation and bioengineered tissues. Studies involving bioengineered tissues and surgical venous ablation demonstrated inconsistent/inconclusive results. Utilization of electrical stimulation in venous ulcer management has not been fully explored. Further studies of dosing electrical stimulation therapy may reveal therapeutic and preventive benefits for managing venous ulcers not yet elucidated.

References

Dec 1, 1978·Archives of Dermatology·D P LookingbillR C Knowles
Jan 1, 1992·The Australasian Journal of Dermatology·A R HalbertA Jopp-McKay
Oct 1, 1992·Annals of Plastic Surgery·T C LundebergM Malm
Mar 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M IeranR Cadossi
Mar 14, 1987·British Medical Journal·K R PoskittC McCollum
Jun 1, 1988·Journal of the American Academy of Dermatology·J M ClancyP L Levick
Jan 1, 1974·Annals of the New York Academy of Sciences·B A RowleyL E Wolcott
Mar 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·B A Rowley
Jul 31, 1982·Lancet·N L Browse, K G Burnand
Aug 1, 1984·The Journal of Dermatologic Surgery and Oncology·H M van den Hoogenband
Jan 1, 1995·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·J StaubesandH Stege
Jul 1, 1994·Physical Therapy·N J SzuminskyJ G Eddy
Aug 1, 1993·The Journal of Dermatologic Surgery and Oncology·V Falanga
Dec 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S M MadsenV T Rosdahl
Aug 3, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·D YangM C Stacey
Aug 27, 1999·The Journal of Bone and Joint Surgery. British Volume·D H Sochart, K Hardinge
Feb 24, 2001·Journal of the American Academy of Dermatology·I C ValenciaW H Eaglstein
Mar 22, 2001·Medical Engineering & Physics·A FranekM Kucharzewski
Aug 7, 2001·International Journal of Health Care Quality Assurance Incorporating Leadership in Health Services·B SvartboL O Bygren
Aug 21, 2001·Angiology·F G FowkesA J Lee
Sep 18, 2001·JAMA : the Journal of the American Medical Association·A H MokdadJ P Koplan
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Mar 26, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P ZamboniA Liboni
Jul 9, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anne-Kathrin TauscheThomas Hunziker
Nov 26, 2003·International Journal of Dermatology·David Fivenson, Lubomira Scherschun
Mar 11, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·Z NavrátilováJ Adler
Mar 17, 2004·Current Opinion in Infectious Diseases·Ruth Edwards, Keith G Harding
Apr 17, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jin Yu LiuGünter Burg
May 4, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A A OmarS Homer-Vanniasinkam
May 11, 2005·Circulation·Robert T Eberhardt, Joseph D Raffetto
Jan 5, 2006·Critical Reviews in Biomedical Engineering·M Clarke-MoloneyP A Grace
Sep 5, 2006·Journal of Vascular Surgery·Wijnand B van GentCees H Wittens
Jan 4, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Martin C RobsonLaurel Wiersma-Bryant
Jul 17, 2008·Archives of Dermatological Research·Aleksandar Janković, Ivana Binić

❮ Previous
Next ❯

Citations

Feb 1, 2017·IEEE Transactions on Bio-medical Engineering·Neha BajwaZachary D Taylor
May 17, 2019·Biomaterials Science·Susheel Kumar NethiSudip Mukherjee
Nov 18, 2020·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Holly Hovan, Jessica Simmons
Jul 31, 2021·Journal of Diabetes Science and Technology·Alejandro Zulbaran-RojasBijan Najafi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Family Physician
Pablo Lopez, Robert Dachs
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
M Frances ValleGerald Lazarus
The Cochrane Database of Systematic Reviews
Simon PalfreymanJonathan A Michaels
© 2021 Meta ULC. All rights reserved