Treatment outcome and dose-response relationship in infants younger than 1 year treated for retinoblastoma with primary irradiation

Medical and Pediatric Oncology
J FontanesiD Meyer

Abstract

Thirty-three infants ( < 1 year at diagnosis) were treated for retinoblastoma with primary irradiation at St. Jude Children's Research Hospital (SJCRH) between 1963 and June 1992. Staging of the 44 treated eyes was as follows: Reese-Ellsworth (R-E) Groups I (n = 20), Group II (n = 9), Group III (n = 6), Group IV (n = 2), Group V (n = 7). Irradiation was delivered using either a single anterior field (31 eyes) or lens-sparing techniques (13 eyes). Total doses ranged from 21-45 Gy (median = 36 Gy) in fractions of 150-180 cGy (n = 34) or > 180 cGy (n = 10). One child died of metastatic disease at 42 months. Three patients have developed second malignant neoplasms; two have succumbed at 88 and 125 months post-RB diagnosis; the remaining patients are alive at 6-259 months postdiagnosis (median follow-up = 127 months). Local control with irradiation alone and supplemented cryotherapy given within 2 months (n = 2) was maintained in 29 eyes, with no statistical difference seen for total doses < or = 36 Gy (21/8 eyes) vs. > 36 Gy (8/16). Of 15 eyes that required salvage therapy, tumor control has been maintained in 13. Enucleation was required for four patients, two with recurrent retinoblastoma and one with a phthisical eye. Cataract f...Continue Reading

References

May 1, 1979·Ophthalmology·P C SalmonsenF D Kitchin
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H W Hethcote, A G Knudson
Oct 1, 1978·Archives of Ophthalmology·P R EgbertA R Rosenthal
Mar 1, 1975·Radiology·D R WeissR Petersen
Aug 1, 1975·American Journal of Ophthalmology·S S Devesa
Dec 1, 1990·Archives of Ophthalmology·H L BrooksJ Fontanesi
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R L FooteJ D Earle
Apr 1, 1989·Ophthalmology·J A ShieldsR Woodleigh
Aug 1, 1987·The British Journal of Radiology·A N HarnettP N Plowman
Feb 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J SchipperH A van Peperzeel
Mar 1, 1986·Archives of Ophthalmology·G T LuederT W O'Gorman
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Jan 1, 1971·The British Journal of Ophthalmology·M A BedfordP A Macfaul
Aug 1, 1969·Radiology·J R CassadyR M Ellsworth
Aug 1, 1982·Archives of Ophthalmology·D H AbramsonF D Kitchin
Jun 1, 1980·International Journal of Radiation Oncology, Biology, Physics·J D GagnonK R Stevens
May 1, 1952·The British Journal of Ophthalmology·H B STALLARD

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Citations

Nov 11, 2009·Archives of Ophthalmology·Gabriel ChodickMargaret A Tucker
Feb 4, 2012·Clinical & Experimental Ophthalmology·Subina NarangCarol L Shields
Sep 30, 2014·Pediatric Blood & Cancer·Amber OrmanPeter A S Johnstone
Dec 27, 2011·International Journal of Radiation Oncology, Biology, Physics·Eman EldebawyCarolyn R Freeman
Jun 12, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·M J KrasinT E Merchant
Oct 10, 2006·Pediatric Blood & Cancer·Guillermo L ChantadaDavid H Abramson
Oct 3, 2003·Journal of Cataract and Refractive Surgery·Harsha BhattacharjeeDipankar Das
Apr 25, 2002·Journal of Pediatric Hematology/oncology·Thomas E MerchantBarrett Haik
Aug 2, 2003·Australasian Radiology·Claire PhillipsJohn McKenzie

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